Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats |
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| Authors: | Yibin Feng Ka-Yu Siu Xingshen Ye Ning Wang Man-Fung Yuen Chung-Hang Leung Yao Tong Seiichi Kobayashi |
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| Affiliation: | (1) School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, SAR, China;(2) Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, SAR, China;(3) Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, Faculty of Science, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, China;(4) Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo, Japan |
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| Abstract: | ![]()
Background Berberine is an active compound in Coptidis Rhizoma (Huanglian) with multiple pharmacological activities including antimicrobial, antiviral, anti-inflammatory, cholesterol-lowering and anticancer effects. The present study aims to determine the hepatoprotective effects of berberine on serum and tissue superoxide dismutase (SOD) levels, the histology in tetrachloride (CCl4)-induced liver injury. |
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