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| 谷胺酰胺预处理对兔脊髓缺血再灌注损伤后血小板聚集及活化功能的影响 | |
| 引用本文： | 巩守平,王文涛,钟大林,吕健,吴锋,车金,僧志远,贺西京. 谷胺酰胺预处理对兔脊髓缺血再灌注损伤后血小板聚集及活化功能的影响[J]. 医学争鸣, 2009, 0(18): 1732-1734 |
| 作者姓名： | 巩守平 王文涛 钟大林 吕健 吴锋 车金 僧志远 贺西京 |
| 作者单位： | 西安交通大学医学院第二附属医院神经外科;西安交通大学医学院血液病实验室;西安交通大学医学院第二附属医院骨科; |
| 摘 要： | 目的：探讨血小板聚集及活化功能在脊髓缺血再灌注损伤（SCIRI）中的变化及谷氨酰胺预处理对其的影响．方法：利用Zivin法建立家兔SCIRI模型，动态监测SCIRI及谷氨酰胺预处理时血小板聚集试验（PAgT）及活化功能特异指标血浆GMP-140浓度的变化．结果：PAgT及GMP-140浓度在缺血45min逐渐升高，持续至再灌注6h，与Sham组相比差异显著（P〈0．01），于再灌注12h下降到缺血前水平（P〉0．05）；谷氨酰胺预处理后血小板进一步活化，高峰期延迟．结论：血小板处于过度活化状态，聚集功能增强，引起凝血功能亢进，可能是参与了脊髓缺血再灌注后神经元损伤与修复过程，谷氨酰胺预处理后血小板进一步活化． |
| 关 键 词： | 缺血再灌注损伤 脊髓 PAgT GMP-140 谷氨酰胺 |
Effect of glutamine precondition on platelet aggregation and activation functions in rabbits with spinal cord ischemia/reperfusion injury |
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| GONG Shou-Ping,WANG Wen-Tao,ZHONG Da-Lin,LU Jian,WU Feng,CHE Jin,SENG Zhi-Yuan,HE Xi-Jing. Effect of glutamine precondition on platelet aggregation and activation functions in rabbits with spinal cord ischemia/reperfusion injury[J]. Negative, 2009, 0(18): 1732-1734 | |
| Authors: | GONG Shou-Ping WANG Wen-Tao ZHONG Da-Lin LU Jian WU Feng CHE Jin SENG Zhi-Yuan HE Xi-Jing |
| Affiliation: | GONG Shou-Ping1,WANG Wen-Tao1,ZHONG Da-Lin1,LU Jian1,WU Feng2,CHE Jin2,SENG Zhi-Yuan1,HE Xi-Jing31Department of Neurosurgery,2Department of Genetics and Molecular Biology,3Department of Orthopedic Surgeon,Second Affiliated Hospital,Medical College,Xi'an Jiaotong University,Xi'an 710004,China |
| Abstract: | AIM: To explore the effect of glutamine precondition on platelet aggregation and activation functions in rats with spinal cord ischemia/reperfusion injury(SCIRI).METHODS:SCIRI models were established with Zivin method in rabbits.The platelet aggregation Test(PAgT)and the plasma GMP-140 were observed dynamically.RESULTS: PAgT and GMP-140 concentration in the IR group started to increase at 45 min after ischemia and continued to increased until 6 h after reperfusion,and then decreased to the level before isch... |
| Keywords: | ischemia/reperfusion spinal cord PAgT GMP-140 glutamine |
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