| 经肝动脉化疗栓塞对兔肝VX2移植瘤生长与转移的影响 |
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| 引用本文： | 吕良山,马清涌,刘亚民. 经肝动脉化疗栓塞对兔肝VX2移植瘤生长与转移的影响[J]. 医学争鸣, 2009, 0(19): 1971-1974 |
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| 作者姓名： | 吕良山 马清涌 刘亚民 |
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| 作者单位： | 西安交通大学医学院第一附属医院消化内科;西安交通大学医学院第一附属医院肝胆外科;西安交通大学医学院第一附属医院周围血管科; |
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| 基金项目： | 陕西省卫生厅自然科学基金(2005) |
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| 摘 要： | 目的：评价经肝动脉化疗栓塞（Transcatheter arterial chemoembolization,TACE）对兔肝VX2移植瘤生长与转移的影响.方法：45只荷瘤兔随机分成3组,每组15只.A组为对照组（Control组）：经肝动脉灌注0.5mL生理盐水;B组为化疗灌注（transcatheter hepatic arterial infusion,TAI）组（TAI组）：经肝动脉灌注5mg阿霉素与0.5mL生理盐水的稀释液;C组为化疗栓塞组（TACE组）：经肝动脉灌注5mg阿霉素与0.5mL碘化油的混悬液.经股动脉穿刺插管,依分组情况行介入治疗.比较不同处理组术后2wk肝移植瘤的增长率、坏死率以及肝内转移、肺转移的发生率.结果：介入治疗前各组肿瘤平均体积之间无显著性差异（P〉0.05）;与对照组及TAI组相比,介入治疗后TACE组肿瘤体积、肿瘤增长率明显降低（P〈0.01）,肿瘤的坏死率明显增加（P〈0.05）,肿瘤的肝内转移、肺转移的发生率明显增加（P〈0.05）.结论：TACE能够抑制兔肝VX2移植瘤的生长,但增加术后肝内转移和肺转移的发生率.
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| 关 键 词： | 化疗栓塞 肝肿瘤 转移 |
Effects of transcatheter arterial chemoembolization on growth and metastasis of rabbit VX2 hepatic tumor |
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| Affiliation: | Lü Liang-Shan1,MA Qing-Yong2,LIU Ya-Min31Department of Gastroenterology,2Department of Hepatobiliary Surgery,3Department of Peripheral Vascular Medicine,First Affiliated Hospital,Medical College,Xi'an Jiaotong University,Xi'an 710061,China |
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| Abstract: | AIM:To evaluate the efficency,as well as effects of transcatheter arterial chemoembolization(TACE)on growth and metastasis of rabbit VX2 hepatic tumor.METHODS:45 rabbits with implanted hepatic VX2 tumor were randomly divided into 3 groups with 15 rabbits in each group.Control group:0.5 mL saline was perfused via hepatic artery in VX2 tumor bearing rabbit models;Transcatheter hepatic arterial infusion(TAI)group:5 mg adriamycin was perfused via hepatic artery in VX2 tumor bearing rabbit models;TACE group:5 mg... |
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| Keywords: | chemoembolization liver cancer metastasis |
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