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| 口腔鳞状细胞癌角蛋白A_(575)表达的病理学特征 | |
| 引用本文： | 马伯龙,龙彦,孙善珍,刘真子,凌涤生. 口腔鳞状细胞癌角蛋白A_(575)表达的病理学特征[J]. 山东大学学报(医学版), 1997, 0(1) |
| 作者姓名： | 马伯龙 龙彦 孙善珍 刘真子 凌涤生 |
| 作者单位： | 山东医科大学口腔病理学教研室 |
| 摘 要： | 运用免疫组化技术ＡＢＣ法观察４３例口腔鳞状细胞癌角蛋白Ａ５７５表达的病理学特征，并对Ａ５７５角蛋白表达与口腔鳞癌的组织学分级、淋巴结转移、临床分期的关系进行了探讨。结果表明，口腔鳞癌组织学分化越低，Ａ５７５角蛋白表达的强度越低。表达强度在以上的Ⅰ级鳞癌为９４．４％；Ⅱ级鳞癌为７８．６％；Ⅲ级鳞癌为３６．４％。Ａ５７５角蛋白表达强度在以上的口腔鳞癌中，有淋巴结转移者为３０％，无转移者为８７．９％，表明Ａ５７５角蛋白表达强度越低，口腔鳞癌转移的可能性越大。Ａ５７５角蛋白表达强度在以上的早晚期口腔鳞癌中分别为９１．７％、５２．６％（Ｐ＜０．０１）。表明临床分期越高，Ａ５７５角蛋白表达强度越低。 |
| 关 键 词： | 癌；鳞状细胞；口腔；角蛋白；免疫组织化学 |
PATHOLOGICAL CHARACTERIZATION OF KERATIN A 575 EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMAS |
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| Ma Bolong Long Yan Sun Shanzhen,et al. PATHOLOGICAL CHARACTERIZATION OF KERATIN A 575 EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMAS[J]. Journal of Shandong University:Health Sciences, 1997, 0(1) | |
| Authors: | Ma Bolong Long Yan Sun Shanzhen et al |
| Abstract: | The expression of cytokeratin A 575 in 43 oral squamous cell carcinomas(OSCC) was observed by means of ABC immunohistochemical technique.The correlation between A 575 expression and the tumor differentiation,lymphonote metastasis,clinical stages were studied.The result showed that the rate of A 575 overexpression in well differentiated,moderate differentiated,poorly differentiated OSCC was 94.4%,78.6%,36.4% respectively.The poorer OSCC differentiated,the weaker keratin A 575 stained.The proportion of A 575 overexpression was 30% in OSCC with lymphonote metastasis,but 89.9% in OSCC without lymphonote metastasis.Cases of lower expression of A 575 seem to have more opportunity of lymphonote metastasis.The immunohistochemical staining with A 575 remarkably decreased in OSCC of advanced stage comparing to those of early stage. |
| Keywords: | Carcinoma Squamous Cell Mouth Keratin Immunohistochemistry |
| 本文献已被 CNKI 等数据库收录！ | |