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Ultrastructural myeloperoxidase activity and expression of myeloid-associated antigens in acute lymphoblastic leukemia
Authors:Hirokazu Taniguchi   Kenjiro Hamamoto   Takahiro Nagano   Yuji Kishimoto   Takashi Kimura   Hideki Fujitake  Kojiro Yasunaga
Affiliation:(1) The First Department of Internal Medicine, Kansai Medical University, 1, Fumizono-cho, 570 Moriguchi, Japan
Abstract:
Ultrastructural myeloperoxidase (MPO) activity and myeloid-associated antigen (MyAg) expression were investigated in 12 adult patients with acute lymphoblastic leukemia (ALL). Ultrastructural MPO was detected by 3 different methods. Immunophenotyping was performed by flow cytometry, using a series of monoclonal antibodies. Ultrastructural MPO-positive blast cells were detected in 6 patients (50%). In 5 of these 6 patients, the methods detecting both MPO and platelet peroxidase (PPO) activities found MPO-positive blast cells more frequently than those detecting MPO activity alone. In 2 patients (17%), at least one kind of MyAg was positive. Ultrastructural MPO activity was detected more frequently than MyAg expression in ALL patients. This method of detecting PPO and MPO is recommended for detection of ultrastructural MPO-positive ALL.
Keywords:Ultrastructural myeloperoxidase activity  Platelet peroxidase activity  Myeloid-associated antigens  Acute lymphoblastic leukemia
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