Low serum C3, leukopenia, and thrombocytopenia: unusual features of Henoch-Schonlein purpura |
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| Authors: | I. Krause B. Z. Garty M. Davidovits R. Cleper H. Tamary E. Rosenmann B. Eisenstein |
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| Affiliation: | (1) Nephrology Clinic and Dialysis Unit, Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel-Aviv University, Petah-Tiqva 49202, Israel, e-mail: ikrause@post.tau.ac.il Tel.: +972-3-9253692; Fax: +972-3-9253913, IL;(2) Department of Paediatrics B and Kipper Institute of Paediatric Allergy and Immunology, Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel-Aviv University, Israel, IL;(3) Haematology Unit, Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel-Aviv University, Israel, IL;(4) Department of Pathology, Rabin Medical Center, Beilinson Campus, Sackler School of Medicine, Tel-Aviv University, Israel, IL |
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| Abstract: | Henoch-Schonlein purpura (HSP) affects predominantly the skin, joints, gastrointestinal tract and kidney. Although the pathogenesis is probably of immune origin and complement activation is thought to play a role, laboratory findings including the serum level of the complement components are usually normal. We present a patient with a severe form of HSP nephritis who had unusual laboratory findings of a low level of C3, mild leukopenia and thrombocytopenia. These findings may further support the importance of complement activation in the pathogenesis of HSP. Received: 1 January 1999 / Accepted: 8 June 1999 |
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| Keywords: | Henoch-Schonlein purpura C3 Hypocomplementemia Nephritis |
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