COX-2、VEGF以及MVD在子宫内膜异位症中的表达及意义

目的通过探讨环氧合酶-2（COX-2）、血管内皮生长因子（VEGF）以及微血管密度（MVD）在子宫内膜异位症（EMs）在位内膜、异位内膜及正常子宫内膜组织中的表达,探讨子宫内膜异位症的发病机制。方法采用免疫组化SP法检测EMs患者32例在位内膜、28例异位内膜及40例对照组正常子宫内膜中COX-2、VEGF的蛋白表达,计数微血管密度（MVD）值,并进行相关性分析。结果 （1）COX-2、VEGF在EMs在位内膜、异位内膜阳性表达率明显高于正常对照组,差异具有统计学意义（P〈0.05）,EMs异位内膜组COX-2、VEGF阳性表达率高于在位内膜组,差异有统计学意义（P〈0.05）。（2）MVD的计数在正常对照组,在位内膜组,异位内膜组依次递增,在位内膜组、异位内膜组与正常对照组比较有统计学差异（P〈0.05）,而在位内膜组与异位内膜组比较有统计学差异（P〈0.05）。（3）EMs在位内膜、异位内膜组患者和正常对照组COX-2蛋白表达与VEGF蛋白及MVD值的变化呈正相关。结论 COX-2与VEGF在EMs中的高表达,与子宫内膜异位的血管生成有关。

Expression of cyclooxygenase-2,vascular endothelial growth factor and the microvessel density in endometriosis and their significance

Objective：To investigate the expression and correlation of cyclooxygenase-2（COX-2）,vascular endothelial growth factor（VEGF）and the microvessel density（MVD）in endometriosis,to explore their roles in the pathogenesis of endometriosis. Methods：The expression to COX-2,VEGF and MVD were assayed by using SP immunohistochemical method in 32 cases of eutopic endometrium,28 cases of ectopic endometrium and 40 cases of normal endometrium,the relationship of the COX-2,VEGF and MVD was analyzed. Results：（1）the expression of COX-2 and VEGF in ectopic endometrium,eutopic endometrium group obviously increased and was significantly higher than in normal group（P0.05）,in ectopic endometrium group was significantly higher than in eutopic endometrium groups（P0.05）.（2）the microvessel density（MVD）increased in endometriosis group and was significantly higher than in normal group（P0.05）,in ectopic endometrium groups it was higher than in eutopic endometrium group（P0.05）.（3）COX-2 expression was positively correlated with the expression of VEGF and MVD in endometriosis. Conclusion：Increased COX-2,VEGF expression are related to angiogenesis in endometriosis.