首页 | 本学科首页   官方微博 | 高级检索  
     


Predictors of punding in Parkinson's disease: results from a questionnaire survey.
Authors:Andrew J Lawrence  Andrew D Blackwell  Roger A Barker  Francesca Spagnolo  Luke Clark  Michael R F Aitken  Barbara J Sahakian
Affiliation:Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom. AJL54@cam.ac.uk
Abstract:
Dopamine replacement therapy (DRT) for Parkinson's disease (PD) has recently been linked to the development of a number of nonmotor behavioral control problems. Punding, one of these nonmotor problems, is a term used to describe complex, purposeless stereotyped behaviors such as the repetitive handling or sorting of objects. A self-report questionnaire was adapted to assess punding in the context of dysfunctional hobby-related activities. We report the results of a survey of PD outpatients from a PD research clinic (n = 141) and non-PD controls (n = 103); conducted to identify clinical and psychological factors predictive of punding behaviors. The PD group reported hobbies and activities, which scored significantly higher on the Punding Scale than controls. Higher impulsivity, poorer disease-related quality of life, younger age of disease onset, and concomitant daily medication dosage from dopamine receptor agonists were independently predictive of higher Punding Scale scores in the PD group. These findings are similar to those seen in dopamine dysregulation syndrome, and provide further evidence for the role of impulsivity and age at disease onset in DRT-related nonmotor behavioral problems in PD.
Keywords:dopamine  side-effects  compulsion  impulsivity  age of onset.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号