Effect of lidocaine on cholera vibrio-induced changes in the jejunum, renal medulla, and lungs of suckling rabbits

Lidocaine injected into suckling rabbits infected with a virulent strain ofVibrio cholerae abolishes the development of hydropic and ballooning degeneration the jejunal enterocytes. Secretory granules and lipid inclusions accumulate in jejunal enterochromaffin cells and interstitial cells of renal medulla, respectively, and are not released into the vascular bed. In pulmonary tissue ultrastructural changes are mild, and capillary epithelium is undamaged, indicating that lidocaine stimulates pulmonary enzymes which inactivate biologically active substances implicated in the pathogenesis of cholera. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6, pp. 632–637, June, 1997