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Eicosanoid production by the mucosa in inflammatory bowel disease after 5-ASA treatment |
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| Authors: | Zijlstra F. J. van Dijk A. P. M. Ouwendijk R. J. Th. van Riemsdijk-Overbeeke I. C. Wilson J. H. P. |
| Affiliation: | 1.Department of Pharmacology, Erasmus University, P.O. Box 1738, 3000 DR, Rotterdam ;3.Department of Internal Medicine II, University Hospital Dijkzigt, Rotterdam ;2.Department of Internal Medicine, Ikazia Hospital, Rotterdam, The Netherlands ; |
| Abstract: | Eicosanoids were measured in biopsies of colonic mucosa from five patients with active ulcerative colitis before and after a four weeks of treatment with 5-amino-salicylic acid (5-ASA). Eicosanoid formation was determined after the addition of14C-arachidonic acid and stimulation with calcium ionophore A23187. 5-ASA given intra-rectally caused a non-selective suppression of prostanoids, leukotrienes and hydroxyeicosatetraenoic acids. Changes in arachidonic acid metabolism after 5-ASA treatment were not always reflected in changes in inflammation score. |
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