Increased sedentary time and decreased physical activity increases lipoprotein associated phospholipase A2 in obese individuals |
| |
| Affiliation: | 1. Human Performance Laboratory, Department of Kinesiology, James Madison University, 261 Bluestone Dr MSC 2302, Harrisonburg, VA, 22807, USA;2. Department of Kinesiology, James Madison University, 261 Bluestone Dr. MSC 2302, Harrisonburg, VA, 22807, USA;1. Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, PR China;2. NHC Key Laboratory of Assisted Circulation (Sun Yat-sen University), Guangzhou, 510080, PR China;3. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China;4. Department of Cardiology, Guizhou Provincial People''s Hospital, Guiyang, 550001, PR China;1. Department of Physiotherapy and Rehabilitation, Faculty of Health Science, Istanbul Medipol University, Istanbul, Turkey;2. Department of Ergotherapy, Faculty of Health Science, Istanbul Medipol University, Istanbul, Turkey;1. Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;2. Division of Cardiology, University Hospital “Tor Vergata”, Rome, Italy;3. Division of Cardiology and Cardiac Intensive Care Unit, San Paolo Hospital, Savona, Italy;4. Cardiocentro Ticino, Lugano, Switzerland;5. Internal Medicine, Gastroenterology and Hepatology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy |
| |
| Abstract: | ![]()
Background and aimsLipoprotein-associated Phospholipase A2 (Lp-PLA2) is a protein produced by inflammatory cells in circulation and is associated with cardiovascular disease (CVD) risk. Physical activity (PA) is known to reduce inflammation and risk for CVD. However, Lp-PLA2 has yet to be examined in relation to PA and sedentary time. The purpose of this study was to determine if PA and sedentary time impacts Lp-PLA2 mass. A total of 25 subjects with an average BMI of 30.6 ± 5.7 were included in the data analysis.Methods and resultsData collected included anthropometric data, Lp-PLA2 mass, peak oxygen uptake (VO2peak), resting heart rate and blood pressure, obstructive sleep apnea (OSA) risk, and assessment of PA using an accelerometer. Sedentary minutes per day was positively associated with Lp-PLA2 (r = 0.41, P < 0.05). Light intensity PA was negatively associated (r = ?0.51. P = 0.01) with Lp-PLA2. When subjects were divided into 2-quantiles by Lp-PLA2, the group with the higher Lp-PLA2 mass accumulated more sedentary time per day (P < 0.001) and less light intensity PA per day (P = 0.001). OSA risk and Lp-PLA2 showed no relationship. Sedentary behavior was higher, and light intensity PA was lower in subjects with hiLp-PLA2 mass. No difference was seen in moderate-to-vigorous intensity PA or steps per day.ConclusionsThis suggests that, total PA habits, including time spent sedentary and lower intensity PA, impacts the levels of Lp-PLA2, an important inflammatory marker and marker of CVD risk. |
| |
| Keywords: | Obesity Sedentary Physical activity Inflammation CVD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" Cardiovascular disease PAF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" Platelet-activating factor PA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" Physical activity OSA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" Obstructive sleep apnea LDL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" Low density lipoprotein VLDL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" Very low-density lipoprotein HDL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" High-density lipoprotein hsCRP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" High sensitivity C-reactive protein IL-6" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" Interleukin-6 TNF-" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" Tumor necrosis factor alpha NO" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" Nitric oxide PARQ+" },{" #name" :" keyword" ," $" :{" id" :" kwrd0160" }," $$" :[{" #name" :" text" ," _" :" Physical activity questionnaire plus IPAQ" },{" #name" :" keyword" ," $" :{" id" :" kwrd0170" }," $$" :[{" #name" :" text" ," _" :" International physical activity questionnaire WC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180" }," $$" :[{" #name" :" text" ," _" :" Waist circumference DXA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0190" }," $$" :[{" #name" :" text" ," _" :" Dual-energy X-ray absorptiometry RHR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0200" }," $$" :[{" #name" :" text" ," _" :" Resting heart rate SBP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0210" }," $$" :[{" #name" :" text" ," _" :" Systolic blood pressure DBP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0220" }," $$" :[{" #name" :" text" ," _" :" Diastolic blood pressure NHANES" },{" #name" :" keyword" ," $" :{" id" :" kwrd0230" }," $$" :[{" #name" :" text" ," _" :" National Health and Nutrition Examination Survey MVPA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0240" }," $$" :[{" #name" :" text" ," _" :" Moderate-to-vigorous intensity physical activity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
