The relationship of skin autofluorescence with diastolic function and HFA-PEFF score in a general population of older people |
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| Affiliation: | 1. Institute of Medical Epidemiology, Biometrics and Informatics, Medical Faculty of the Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany;2. Department of Internal Medicine III - Cardiology, Mid-German Heart Center, University Hospital Halle (Saale), Halle, Germany;3. Department of Cardiac Surgery, Mid-German Heart Center, University Hospital Halle (Saale), Halle, Germany;4. Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany;1. Department of Experimental and Clinical Medicine, University of Florence, Italy;2. Unit of Clinical Nutrition, Careggi University Hospital, Florence, Italy;1. Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India;2. Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India;3. Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India;4. Department for Management of Noncommunicable Diseases, Disability, Violence and Injury Prevention (NVI), World Health Organization, Geneva, Switzerland;1. Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens, Greece;2. School of Medicine Sydney, University of Notre Dame, Sydney, Australia;3. First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece;4. School of Psychology, University of Surrey, Guildford, UK;5. Faculty of Health, University of Canberra, Canberra, Australia;1. Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico;2. Department of Nephrology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico;3. Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico |
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| Abstract: | ![]()
Background and aimsAdvanced glycation end-products accumulation in tissue as measured by Skin autofluorescence (SAF) is related to diastolic function in specific patient populations. This analysis aims at investigating this relationship in a general population of older persons.Methods and resultsBased on data from the CARLA cohort at first follow-up, 245 subjects were analyzed and stratified according to cardiovascular risk factors (CVRF). We used linear regression to investigate the association between diastolic function evaluated by echocardiography, HFA-PEFF score, and SAF.Univariable regression analysis showed an association of SAF with septal-E/e’ (standardised beta = 1.11, 95% CI = 0.51–1.71) and A (3.42, 95% CI = 0.72–6.12), the former persisting after adjustment for age, sex and CVRF (0.67, 95% CI = 0.05–1.28). Septal-E/e’ remained related to SAF only in the high cardiovascular risk stratum (1.16, 95% CI = 0.26–2.06). SAF was related to HFA-PEFF score (0.27, 95% CI = 0.10–0.43) but not after correcting for age and sex (0.16, 95% CI = 0.00–0.32) and CVRF and glomerular filtration rate (0.12, 95% CI = ?0.07 – 0.27). SAF was related to the HFA-PEFF score only for participants with high cardiovascular risk (0.23, 95% CI = 0.02–0.45).ConclusionIn a general community-dwelling older population, SAF is related to diastolic function as measured by septal-E/e’. Further research is necessary to assess if SAF is a potential screening tool for diastolic dysfunction in advanced age. |
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| Keywords: | Advanced glycation end-products Skin autofluorescence Diastolic function Heart failure HFA-PEFF Older persons Elderly AGEs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" Advanced glycation endproducts ASE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" American Society of Echocardiography BMI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" Body mass index CV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" Cardiovascular CVRF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" Cardiovascular risk factors DD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" Diastolic dysfunction EACVI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" European Association of Cardiovascular Imaging eGFR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" Estimated glomerular filtration rate HFpEF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" Heart failure with preserved ejection fraction LAVI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" Left atrial volume index LV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" Left ventricular LVMI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0160" }," $$" :[{" #name" :" text" ," _" :" Left ventricular mass index LVWT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0170" }," $$" :[{" #name" :" text" ," _" :" Left ventricular wall thickness RWT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180" }," $$" :[{" #name" :" text" ," _" :" Relative wall thickness SAF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0190" }," $$" :[{" #name" :" text" ," _" :" Skin autofluorescence SD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0200" }," $$" :[{" #name" :" text" ," _" :" Standard deviation |
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