Total and differential white blood cell count and cause-specific mortality in 436 750 Taiwanese adults |
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| Institution: | 1. Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China;2. Department of Public Health, National Cheng Kung University, Tainan, Taiwan;3. School of Public Health, Sun Yat-sen University, Guangzhou, China;4. Institute of Sociology, Academia Sinica, Taipei, Taiwan;5. Department of Sociology, The Chinese University of Hong Kong, Hong Kong SAR, China;6. Division of Environment and Sustainability, The Hong Kong University of Science and Technology, Hong Kong SAR, China;7. Department of Civil and Environmental Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China;1. Diabetology, Careggi Hospital, University of Florence, Italy;2. Diabetology, ASUI, Trieste, Italy;3. FAND, Milan, and FederDiabete Lazio, Rome, Italy;4. Endocrinology and Metabolic Diseases, Hospital of Alessandria, Italy;5. Fondazione Policlinico Universitario A. Gemelli IRCCS and Università Cattolica del Sacro Cuore, Rome, Italy;6. University of Florence, Italy;7. Formerly Diabetology, San Martino Hospital, Genova, Italy;8. Società Italiana di Medicina Generale (SIMG), Italy;9. Diabetology, Niguarda Ca’ Granda Hospital, Milan, Italy;10. Endocrinology, Diabetology and Metabolic Diseases, University of Verona, Italy;11. Laboratory of Clinical Pedagogy, University of Turin, Italy;12. Scuola Superiore S. Anna, Pisa, Italy;1. School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai 200032, China;2. School of Public Health, Department of Epidemiology, Shanxi Medical University, Taiyuan, 030001, China;3. Songjiang District Centre for Disease Prevention and Control, Shanghai, 201600, China;4. Department of Public Health and Community Medicine, Institution of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;1. Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy;2. Department of Pediatrics and Gynecology, Hospital of Belluno, AULSS 1, Belluno, Italy;1. Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan;2. Department of Internal Medicine, Matsushita Memorial Hospital, Osaka, Japan;3. Medical Corporation Soukenkai, Nishimura Clinic, Kyoto, Japan;1. Division of Cardiology, Ospedale degli Infermi, ASL Biella, Biella, Italy;2. Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy;3. Clinical Chemistry Ospedale degli Infermi, ASL Biella, Biella, Italy;4. Dipartimento di Scienze della Sanità Pubblica e Pediatriche, Università degli Studi di Torino, Italy;5. Clinical Chemistry, Azienda Ospedaliera-Universitaria “Maggiore della Carità”, Università del Piemonte Orientale, Novara, Italy;6. Radiology, Azienda Ospedaliera-Universitaria “Maggiore della Carità”, Università del Piemonte Orientale, Novara, Italy;7. Division of Cardiology, Azienda Ospedaliera-Universitaria “Maggiore della Carità”, Università del Piemonte Orientale, Novara, Italy;1. Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing 100069, China;2. Physical Examination Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;3. Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China |
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| Abstract: | Background and aimsWhite blood cell (WBC) count is an easily obtainable biomarker of systematic inflammation. Our study aimed to investigate the associations of differential WBC count with all-cause and cause-specific mortality in a general Asian population.Methods and resultsCox proportional hazards model was used to evaluate the associations of WBC count with mortality separately for men and women, with adjustment for multiple variables including age, smoking, and other lifestyle factors. Stratified analyses by age, smoking, diabetes, and hypertension were conducted to explore potential effect modification.Elevated WBC count was significantly associated with increased mortality risk. The adjusted hazard ratios of total WBC (10th decile compared to decile of lowest risk) for all-cause mortality were 1.42 (95% CI: 1.33, 1.53) for men and 1.54 (95% CI: 1.42, 1.68) for women. Similar risks were observed for neutrophils, monocytes, and neutrophil/lymphocyte (NL) ratio. The highest deciles of neutrophils, monocytes, and NL ratio were also positively associated with risk of cardiovascular/cerebrovascular, cancer, and respiratory mortality after adjusting for covariates. Results for all-cause mortality remained statistically significant for participants who were <60 years old, non-smokers, non-diabetic, and non-hypertensive.ConclusionsTotal and differential WBC counts (neutrophils, monocytes, and NL ratios) are positively associated with increased risk of all-cause mortality, cardiovascular and cerebrovascular, cancer, and respiratory mortality among Taiwanese adults. |
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| Keywords: | White blood cell count Systemic inflammation Cause-specific mortality BMI"} {"#name":"keyword" "$":{"id":"kwrd0030"} "$$":[{"#name":"text" "_":"body mass index HR"} {"#name":"keyword" "$":{"id":"kwrd0040"} "$$":[{"#name":"text" "_":"hazard ratio CI"} {"#name":"keyword" "$":{"id":"kwrd0050"} "$$":[{"#name":"text" "_":"confidence interval NL ratio"} {"#name":"keyword" "$":{"id":"kwrd0060"} "$$":[{"#name":"text" "_":"neutrophil/lymphocyte ratio WBC"} {"#name":"keyword" "$":{"id":"kwrd0070"} "$$":[{"#name":"text" "_":"white blood cell |
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