Association of weight-adjusted-waist index with all-cause and cardiovascular mortality in China: A prospective cohort study |
| |
| Institution: | 1. Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China;2. Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China;3. Department of Cardiology, Inner Mongolia People''s Hospital, Inner Mongolia, China;4. Department of Cardiology, Peking University First Hospital, Beijing, China;5. Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center, Nanchang of Jiangxi, China;1. Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy;2. Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy;3. Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Palermo, Italy;1. Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia;2. Department of Kinesiology, University of Georgia, Athens, USA;3. The Nuffield Department of Women''s & Reproductive Health, University of Oxford, Oxford, UK;4. Murdoch Children''s Research Institute, Melbourne, Australia;5. Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia;6. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland;7. Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland;1. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal St, Suite 2000, New Orleans, LA, 70112, USA;2. Tulane University Translational Science Institute, 1440 Canal St, Suite 2000, New Orleans, LA, 70112, USA;3. Department of Medicine, Tulane University School of Medicine, 131 S. Robertson St, New Orleans, LA, 70112, USA;1. Department of Internal Medicine, “S. Maria Delle Grazie”, Pozzuoli Hospital, Naples, Italy;2. Obesity and Endocrine Disease Unit, Department of Neuroscience, Santobono-Pausilipon Children''s Hospital, Naples, Italy;3. Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism, University of Verona, Italy;4. Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Naples, Italy;5. Department of Human Pathology in Adulthood and Childhood, University of Messina, Messina, Italy;6. Department of Movement Sciences and Wellbeing, University of Naples Parthenope, Naples, Italy;1. Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;2. Department of Biostatistics and Medical Record, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;3. NAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;4. Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;5. Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton General Hospital, Southampton, UK;6. Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy;7. Institute of Hepatology, Wenzhou Medical University, Wenzhou, China;8. Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China |
| |
| Abstract: | Background and aimsAs a new simple anthropometric index, the weight-adjusted-waist index (WWI) appears to be superior to body mass index (BMI) and waist circumference (WC) in assessing both muscle and fat mass. We aimed to explore the association of WWI with all-cause and cardiovascular mortality in southern China.Methods and resultsA total of 12,447 participants (mean age, 59.0 ± 13.3 years; 40.6% men) in Jiangxi Province from the China Hypertension Survey study were included. WWI was defined as WC divided by the square root of weight. The outcome was all-cause and cardiovascular mortality. During a median follow-up of 5.6 years, 838 all-cause deaths occurred, with 390 cardiovascular deaths. Overall, there was a nonlinear positive relationship of WWI with all-cause and cardiovascular mortality. Accordingly, compared with participants in quartiles 1–3 (<11.2 cm/√kg), a significant higher risk of all-cause mortality (HR: 1.36, 95% CI: 1.17, 1.58) and cardiovascular mortality (HR: 1.43, 95% CI: 1.15, 1.77) were found in quartile 4 (≥11.2 cm/√kg). Further adjustment for BMI and WC did not substantially alter the results. No significant interactions were found in any of the subgroups (sex, age, area, physical activity, current smoking, current alcohol drinking, hypertension, and stroke).ConclusionHigher WWI levels (≥11.2 cm/√kg) were associated with increased the risk of all-cause and cardiovascular mortality in southern China. These findings, if confirmed by further studies, suggested that WWI may serve as a simple and effective anthropometric index in clinical practice. |
| |
| Keywords: | Weight-adjusted-waist index All-cause mortality Cardiovascular mortality Obesity Chinese population Cohort study |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
