Enhancement of stress-induced analgesia in adrenalectomized mice: Its reversal by dexamethasone |
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| Authors: | P. Marek I. Panocka G. Hartmann |
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| Affiliation: | 1. Institute of Genetics and Animal Breeding Polish Academy of Sciences, Jastrz?biec, 05-551 Mroków, Poland;2. Department of Behavioral Physiology Polish Academy of Sciences, Jastrz?biec, 05-551 Mroków, Poland |
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| Abstract: | ![]()
Adrenalectomy significantly increased the level of analgesia induced by room temperature swimming in mice, as revealed by a hot-plate test. This augmentation of antinociceptive action of stress was abolished by dexamethasone pretreatment. Involvement of pituitary opioids in modulating post-stress pain sensitivity in mice is suggested. |
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| Keywords: | Stress Analgesia Pain Adrenal cortex Dexamethasone |
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