T-SPOT.TB、痰涂片和TB—DNA检测在肺结核诊断中的比较研究 |
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引用本文: | 张玉平,丁显平,张丽媛,李晓阳,丁敏,李凌霄. T-SPOT.TB、痰涂片和TB—DNA检测在肺结核诊断中的比较研究[J]. 成都医学院学报, 2013, 8(1): 49-51 |
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作者姓名: | 张玉平 丁显平 张丽媛 李晓阳 丁敏 李凌霄 |
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作者单位: | 张玉平(四川大学生命科学学院遗传医学研究所,特色生物资源研究与利用川渝共建重点实验室,成都610064);丁显平(四川大学生命科学学院遗传医学研究所,特色生物资源研究与利用川渝共建重点实验室,成都610064);张丽媛(四川大学生命科学学院遗传医学研究所,特色生物资源研究与利用川渝共建重点实验室,成都610064);李晓阳(四川大学生命科学学院遗传医学研究所,特色生物资源研究与利用川渝共建重点实验室,成都610064);丁敏(四川大学生命科学学院遗传医学研究所,特色生物资源研究与利用川渝共建重点实验室,成都610064);李凌霄(四川大学生命科学学院遗传医学研究所,特色生物资源研究与利用川渝共建重点实验室,成都610064); |
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摘 要: | 目的评价T—SPOT.TB、痰涂片和TBDNA3种方法对肺结核病人的临床应用价值。方法应用T—SPOT.TB、痰涂片和TBDNA3种检测方法分别对确诊组130例肺结核(TB)患者及60例非结核疾病患者进行检测。结果T—SPOT.TB、痰涂片和TB-DNA在肺结核检测中的敏感性分别为92.31%、26.15%、71.54%,在对照组中其特异性分别为93.33%、100%、97.87%。T—SPOT.TB在“涂阴”肺结核中的阳性率为94.79%,在TH-DNA检测阴性的肺结核中检出率为94.59%。结论3种方法中,痰涂片敏感性最低,T—SPOT.TB最高,极大地减少了结核的漏检率,可以成为结核病早期诊断的一项有效的辅助检查手段。
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关 键 词: | 结核病 T -SPOT TB 痰涂片 TB-DNA |
Comparative Research of T-SPOT. TB,Sputum Smear and TB-DNA Test in the Diagnosis of Tuberculosis |
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Affiliation: | ZHANG Yu- ping, DING Xian-ping ,ZHANG Li yuan, LI Xiao-yang, DING Min, LI Ling xiao ( SichuarvChongqing Joint Key Laboratory for Bio resource Research and Utilization, Institute of Medical Genetics, School of Life Science, Sich uan University, Chengdu 610064, China ) |
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Abstract: | Objective To evaluate the clinical value of T- SPOT. TB, Sputum Smear and TBDNA for the diagnosis of tuberculosis. Methods Using T-SPOT. TB,Sputum Smear and TB DNA, 130 cases of TB in confirmed tuberculosis group and 60 non TB patients were tested. Results The sensibility of T-SPOT. TB,Sputum Smear and TB-DNA in tuberculosis detection were 92. 31%,26. 1% and 71. 54%, respectively. The specificity of T SPOT. TB,Sputum Smear and TB-DNA in control group were 93. 33%,100% and 97. 87% ,respectively. The positive rate of T- SPOT. TB in the Tuberculosis group which was positive by Sputum Smear and in the Tuberculosis group which was positive by TB-DNA were 94.79 %and 94.59 %, respectively. Conclusion Among the three methods, the sensitivity of Sputum Smear was the lowest,and the sensitivity of T SPOT. TB was the highest. T-SPOT. TB can greatly reduce the rate of missing inspection of tuberculosis, therefore it can be used as an effective and assistant method for rapid diagnosis of tuberculosis. |
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Keywords: | Tuberculosis T SPOT. TB Sputum Smear TB-DNA |
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