50岁以下冠心病患者危险因素分析

目的研究50岁以下冠心病患者危险因素,对高危中青年人的冠心病一级预防提供参考。方法根据156例冠状动脉造影结果将50岁以下行冠脉造影者分为冠心病组(89例)和非冠心病组(67例),收集临床心血管危险因素资料进行Logistic多因素回归分析。结果156例冠状动脉造影者中89例诊断为冠心病(57.1%),67例无冠心病(42.9%)。Logistic多因素回归分析显著冠心病家族史、血浆总胆固醇水平及吸烟为冠心病的独立危险因素,其相关系数分别为0.63、0.50、0.97,优势比(OR)分别为1.06、1.65、2.64(P<0.05)。结论冠心病家族史、血浆总胆固醇水平高及吸烟是中青年人冠心病发生的高危因素,对这类人群应尽早干预。

Risk factor analysis in patients with coronary artery disease under 50 years old

Objective To determine risk factors in patients with coronary artery disease (CAD) under 50 years old. Methods 156 adults under 50 years old who had undergone coronoray angiography were divided into 2 group: Group 1 (n=89) with evidence of angiographic CAD and group 2 (n=67) with non-CAD as control. The CAD risk factors were also studied. Results In 156 adults under 50 years old 89 persons had angiographic CAD (57.1%) and 67 persons had non-CAD (42.9%). By multivariate logistic regression analysis, family history of CAD, high-total blood cholesterol level and smocking were conformed to be independent risk factor for CAD. The old ratios (OR) were 0.63, 0.50, 0.97 (P<0.05) and relative coefficient were 0.63, 0.50, 0.97 (P<0.05) respectively. Conclusion Family history of CAD, high-total blood cholesterol level and smoking were conformed to be independent risk factor in patients in middle-age and young adults. High degree attention and proper life style control should be paid to such a group.