Role of postdose cyclosporine monitoring in living renal transplant recipients

Achieving optimal cyclosporine (Neoral) absorption is critical for successful graft outcome. Recently there have been studies on postdose monitoring of cyclosporine. Two- and 3-hour postdose cyclosporine levels measured by radioimmunoassay were correlated with occurrence of rejection and cyclosporine nephrotoxicity in 30 patients; C₂ and C₃ levels were significantly lower than the desired therapeutic levels in patients with acute rejection. Based on our study and those of others we suggest C₃ levels should be adopted in clinical practice.