厄贝沙坦对2型糖尿病SD大鼠胰岛结构和功能的影响

目的：观察厄贝沙坦干预对2型糖尿病（T2DM）大鼠胰岛结构和功能的影响,以探讨其保护胰岛结构和功能的可能机制.方法：40只SD大鼠随机分为4组,每组10只,即A组（普通饲料组）,B组（高糖高脂饲料组）,C组（T2DM对照组）、D组（厄贝沙坦干预组）.观察厄贝沙坦干预对T2DM大鼠血糖、胰岛素等胰岛结构和功能的影响.结果：D组与C组比较,空腹血糖下降25.08％,稳态模型评价胰岛素抵抗指数下降30.87％,ISI提高了11.93％,明显改善糖耐量.D组与C组大鼠比较,胰岛内β细胞相对量增加67.35％,胰岛β细胞内胰岛素水平增加43.86％,胰岛β细胞胰岛素mRNA表达水平增高9.79％.结论：厄贝沙坦干预可降低T2DM大鼠空腹血糖、HOMA-IR,提高ISI,改善胰岛结构和功能.

EFFECT OFIRBESARTAN ON THE STRUCTURE AND FUNCTION OF ISLET IN TYPE 2 DIABETIC SD RATS

Objective：To detect the effects of irbesartan intervention on structure and function of islet β-cells in type 2 diabetic Sprague-Dawly （SD） rats,and to explore the possible mechanisms.Methods：Forty SD rats were randomly divided into groups A （normal diet）,B （high glucose and high fat diet）,C （type 2 diabetic control） and D （irbesartan intervention）,10 rats in each group.Fasting blood glucose （FBG）,insulin,and structure and function of islet β-cells were detected 12 weeks after irbesartan intervention.Results：Compared to group C,12 weeks after irbesartan intervention,FBG and homeostasis model assessment of insulin resistance （HOMA-IR） in group D decreased 25.08％ and 30.87％,respectively; and insulin sensitivity index （ISI） of group D increased 11.93％.Irbesartan intervention improved the early phase of insulin secretion and glucose tolerance in SD rats significantly.The relative amounts of β-cells,insulin levels and expression levels of insulin-mRNA in the islet β-cells in group D increased 67.35％,43.86％ and 9.79％,respectively.Conclusion：Irbesartan intervention could decrease FBG,HOMA-IR and increase ISI,and improve the structure and function of islet β-cells.