|
|||||
|
|
Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome |
|
| Authors: | Siarey R J Carlson E J Epstein C J Balbo A Rapoport S I Galdzicki Z |
| Affiliation: | a Laboratory of Neurosciences, NIA, NIH, Bethesda, MD 20892, USA b Department of Pediatrics, University of California, San Francisco, CA 94143, USA |
| Abstract: | Long-term potentiation (LTP) and depression (LTD) were investigated in hippocampus of a genetic model of Down syndrome, the segmental trisomy (Ts65Dn) mouse. Field excitatory postsynaptic potentials were recorded from hippocampal slices and LTP and LTD evoked sequentially. LTP decreased whereas LTD increased significantly in Ts65Dn compared with control hippocampus. |
| Keywords: | Down syndrome Ts65Dn Long-term potentiation Long-term depression Hippocampus Mental retardation |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |