首次发病与复发抑郁症患者执行功能的对照研究

目的:探讨首发和复发抑郁症患者执行功能损害情况。方法:采用威斯康星卡片分类测验(WCST)、Stroop测验、汉密尔顿抑郁量表(HAMD-17)对100例抑郁症患者进行评定,其中首次发病(首发组)患者41例,复发(复发组)患者59例;同时以50名正常人作为对照组进行测评并分析比较。结果:在WSCT的总错误数、分类完成数、持续性错误数及持续性应答数、以及Stroop色词测验的彩色文字阅读(Stroop-c)时间和彩色文字的色彩阅读(Stroop-cw)正确数上,首发组、复发组与对照组之间差异均有统计学意义(P0.05或P0.01);Stroop-c正确数上首发组和复发组之间差异无统计学意义(P0.05)。结论:无论首发还是复发抑郁症患者均存在明显的执行功能损害,复发者更为显著。

Control study on executive function between patients with first-episode and recurrent depression

Objective： To explore the impairment of executive function between patients with first-epi- sode and recurrent depression. Method：The Wisconsin card sorting test （WCST）, Stroop test, Hamilton depression scale （HAMD-17） were used to evaluate 100 depressive patients, in which the first onset patients （first-episode group） 41 cases, recurrence patients （recurrent group） 59 cases. The results were compared with 50 normal controls. Results：There were statistically significant difference among the first-episode group, the recurrent group and the control group （P 〈 0.05 or P 〈 0.01 ） on the total number of errors, classification num- ber, perseverative errors, sustained responders of the WCST,time of Stroop-c and correct number of Stroop-cw, but no statistically significant difference on the Stroop-c correct number between the first episode group and the recurrent group （ P 〉 0.05 ）. Conclusion： There are significant impairment of executive function in patients with first-episode and recurrent depression, which in recurrent depression patients are more obvious impairment.