精神分裂症患者血清性激素水平及其与临床特征的相关性

目的:探讨精神分裂症患者血清性激素水平变化及其与精神症状、认知功能的相关性。方法:检测84例精神分裂症患者(病例组)治疗前后血清泌乳素(PRL)、睾酮(T)及雌二醇(E2)水平,并与42例非精神分裂症患者(对照组)比较;分析病例组血清性激素水平与阳性与阴性症状量表(PANSS)评分、数字符号测验、数字广度、语义流畅性测验评分的相关性。结果:病例组治疗前后血清PRL、T水平明显高于对照组(P均0.05);与治疗前比较,治疗后血清PRL明显升高、T明显降低(P均0.05)。女性病例组治疗前后血清E2浓水平明显低于对照组(P均0.05)。病例组血清PRL、T及E2水平与PANSS总分、及各认知功能测验评分无相关(P均0.05),血清T水平与PANSS中兴奋性、冲动控制障碍评分呈正相关(r=0.26,r=0.33;P均0.05)。结论:精神分裂症患者血清性激素水平异常,但与其病情和认知功能改变不相关;但血清T水平可能适用于其临床兴奋、冲动的风险评估。

Correlation between serum sex hormone levels and clinical features in patients with schizophrenia

Objective： To explorer the variation of serum sex hormone levels in patients with schizophrenia,and correlation with mental sympotoms and cognitive function.Method：The serum prolactin （PRL）,testosterone （T）,and estrodiol （E2） levels in 84 patients with schizophrenia （case group） were detected before and after treatment.The results were compared with 42 patients with non-schizophrenia （control group）.The correlation between serum sex hormone levels with scores of positive and negative syndrome scale （PANSS）,digit symbol test,digit span,semantic fluency test in case group were analyzed.Results：The serum PRL and T evels in case group before and after treatment were significantly higher than those in control group （all P〈0.05）. Compared to before treatment,the level of PRL was increased,and T was decreased significantly after treatment （all P〈0.05）.The levels of E2 in case group female before and after treatment were significantly lower than control group （all P〈0.05）.The serum PRL,T and E2 levels were not correlated to PANSS total score,and the cognitive function test scores in case group.Serum T levels was positively correlated to the scores of excitability,impulse control disorder in PANSS （r=0.26,r=0.33;all P〈0.05）.Conclusion： The levels of serum sex hormone in patients with schizophrenia are abmormal,but which not correlated to their illness and cognitive function,but serum T level may apply to their excited and impulsive clinical risk assessment.