支气管哮喘患者诱导痰中白介素水平及与气道炎症的关系

目的探讨支气管哮喘患者诱导痰中白介素17（IL-17）、白介素8（IL-8）的水平,并分析与气道炎症的关系。方法分别选择轻度（轻度组）、中度（中度组）和重度（重度组）支气管哮喘急性发作期患者20例、18例和15例,正常对照组15例,采用酶联免疫吸附测定（ELISA）法检测诱导痰IL-17和IL-8浓度。结果 IL-17水平重度组与轻度组、中度组和正常对照组比较,有统计学意义（P〈0.05）。与正常对照组比较,IL-8在重度组显著升高,在轻度和中度组亦有升高趋势,相互比较差异有统计学意义（P〈0.05）。结论 IL-17及IL-8可能参与气道炎症的形成。

Asthma induced sputum interleukin levels and the relationship between airway inflammation

Objective Induced sputum of asthmatic patients the level of interleukin 17,8,and analysis of the relationship between airway inflammation.MethodsWe selected mild（mild group）,moderate（moderate group） and severe（severe group） 20 patients with persistent asthma,18 cases and 15 cases,15 normal controls,using enzyme-linked immunosorbent assay（ELISA） detected by sputum IL-17 and IL-8 concentration.ResultsMild,moderate and severe asthma,induced sputum eosinophile ratio compared with the control group were statistically significant differences（P〈0.05）;However,asthma patients in each group no significant difference between（P〈0.05,Table 2）.The ratio of neutrophil with mild and severe group,moderate group and normal control group was significantly（P〈0.01）.IL-17 levels and severe group and mild group,moderate group and normal control group was significantly（P〈0.05）.Compared with the control group,IL-8 in the severe group was significantly higher in mild and moderate groups have increasing trend,there was significant difference between each other（P〈0.05）.ConclusionIL-17 and IL-8 may be involved in the formation of airway inflammation.