胃肠间质瘤靶向治疗的影像学评价

影像学是评价胃肠间质瘤（GIST）靶向治疗疗效的重要手段。RECIST形态学标准在靶向治疗中的应用存在一定限度．主要表现为基于传统径线评效不能准确地反映疗效变化。结合肿瘤径线及CT值变化率的Choi评效标准．拓展了影像学在GIST靶向治疗评价疗效的应用价值。新近的研究显示．磁共振扩散加权成像（DWI）表观扩散系数（ADC）值的变化,可早期反映GIST靶向治疗疗效．有效者在初始治疗后1周内即可出现ADC值的显著改变。通过基于肿瘤生物学行为影像因素的综合分析,可为胃肠间质瘤靶向治疗评效提供新的途径。

Imaging evaluation of targeted therapy for gastrointestinal stromal tumor

Imaging study is the primary method to evaluate the efficacy of targeted therapy for gastrointestinal stromal tumor(GIST). The application of RECIST morphological criteria has limitations in the evaluation of targeted therapy, which may result in incorrect reflection of responses by conventional size-based criteria. Recent proposed Choi criteria, which combined the size and the CT value, has extended the application of radiology in the evaluation of GIST. The early change of apparent diffusion coefficient(ADC) values on diffusion-weighted imaging(DWI) can reflect the response of GIST to targeted therapy. The prominent change of ADC can be detected within one week after therapy. Through comprehensive analysis of the imaging characterisitics associated with the biological behavior of GIST, new approaches may be developed in the evaluation of response of GIST to targeted therapy.