| 半乳糖化重组人生长激素和重组人生长激素在小鼠体内的药物动力学 |
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| 引用本文： | 李静 李铜玲. 半乳糖化重组人生长激素和重组人生长激素在小鼠体内的药物动力学[J]. 中国临床药学杂志, 1999, 8(1): 33-36 |
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| 作者姓名： | 李静 李铜玲 |
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| 作者单位： | [1]上海医科大学药学院 [2]华西医科大学药学院临床药学教研室 |
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| 基金项目： | 国家自然科学基金资助(编号 39670861) |
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| 摘 要： | 目的：比较半乳糖化重组人生长激素和重组人生长激素在小鼠体内的药物动力学特征。方法：用＾１２５Ｉ标记Ｇａｌ－ｒｈＧＨ和ｒｈＧＨ、通过小鼠尾静脉ｉｖ,测定血和肝中相对放射性随时间的变化,以３Ｐ８７药物动力学程序进行模型拟合和参数求算。结果：＾１２５Ｉ－ｒｈＧＨ－Ｇａｌ在血中的相对放射性呈现双峰,其体内药行动力学特征与＾１２５Ｉ－ｒｈＣＨ明显不同,进一步证实了Ｇａｌ－ｒｈＧＨ的肝靶向性。
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| 关 键 词： | 生长激素 半乳糖化 重组 药物动力学 同位素 |
Comparison of the pharmacokinetics between galactosed recombinant human growth hormone and recombinant human growth hormone |
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| Li Jing,Li Tongling,Pang Qijie,et al The College of Pharmacy,West China University of Medical Sciences,Chengdu. Comparison of the pharmacokinetics between galactosed recombinant human growth hormone and recombinant human growth hormone[J]. Chinese Journal of Clinical Pharmacy, 1999, 8(1): 33-36 |
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| Authors: | Li Jing Li Tongling Pang Qijie et al The College of Pharmacy West China University of Medical Sciences Chengdu |
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| Affiliation: | Li Jing,Li Tongling,Pang Qijie,et al The College of Pharmacy,West China University of Medical Sciences,Chengdu 610041 |
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| Abstract: | AIM : To compare the pharmacokinetics of galactosed recombinant human growth hormone (Gal-rhGh) and recombinant human growth hormone(rhGH). METHODS: ~(125)I-Gal-rhGH and 125I -rhGH was labeled with chloramine-T method. They were given to mice by iv, respectively. The pharmacokinetics of them were investigated by computer program 3P87. RESULTS: The relative radioactivity of 125I -Gal-rhGH had double peaks in blood. There were significant different pharmacokinetic characters between 125I -Gal-rhGH and 1251-rhGH. CONCLUSION: The pharmacokinetic difference between 125I-Gal-rhGH and 125I -rhGH is successfully compared by isotope tracer labeling method. |
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| Keywords: | recombinant human growth hormone galactosed recombinant human growth hormone pharmacokinetics isotope tracer labeling method |
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