| 辛伐他丁治疗老Ⅱ型糖尿病脂代谢紊乱的疗效 |
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| 引用本文： | 王中丽 杨香玖. 辛伐他丁治疗老Ⅱ型糖尿病脂代谢紊乱的疗效[J]. 中国临床药学杂志, 1999, 8(2): 74-78 |
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| 作者姓名： | 王中丽 杨香玖 |
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| 作者单位： | 湖北医科大学附属第二医院老年内分泌科 武汉430071 |
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| 摘 要： | 目的：探讨辛伐他丁对老年Ⅱ型糖尿病脂代谢紊乱患者的疗效。方法：３０例老年Ⅱ型糖尿病脂代谢紊乱患者予辛伐他丁片５￣２０ｍｇ ｑｎ，用药４ｗｋ。结果：辛伐他丁降低ＴＣ２５％，ＬＤＬ－Ｃ降低２５％，降低ＴＧ２２．８％。ＨＤＬ－Ｃ降低者有升高作用，且降低ＴＣ／ＨＤＬ－Ｃ２１．８％，也降低载脂蛋白Ｂ１８％。对血糖水平无不良影响。结论：辛伐他丁用于老年Ⅱ型糖水病脂代谢异常患者安全、有效。
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| 关 键 词： | 糖尿病 调脂 辛伐他丁 脂代谢紊乱 |
The clinical efficacy of simvastatin in treating lipid metabolic disorder in the senile type-II diabetes |
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| Wang Zhongli,Yang Xiangjiu,Wang Hua,et al Second Affiliated Hospital of Hubei Me-dical University Endocrinologyment,Wuhan. The clinical efficacy of simvastatin in treating lipid metabolic disorder in the senile type-II diabetes[J]. Chinese Journal of Clinical Pharmacy, 1999, 8(2): 74-78 |
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| Authors: | Wang Zhongli Yang Xiangjiu Wang Hua et al Second Affiliated Hospital of Hubei Me-dical University Endocrinologyment Wuhan |
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| Affiliation: | Wang Zhongli,Yang Xiangjiu,Wang Hua,et al Second Affiliated Hospital of Hubei Me-dical University Endocrinologyment,Wuhan 430071 |
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| Abstract: | AIM:To know the curative efficacy of treating the senile type- I diabetic lipid metabolic disorder with HMG-CoA reducing enzyme depressor simvastatin. METHODS: Thirty patients of senile type-I diabetics lipid metabolic disorder toke simvastatin 5-20 mg/d in evening for 4 wk. RESULTS:Simvastatin reduced serum cholesterol 25%,reduced low densty lipoprotein 25%, reduced triglyceride 22. 8%,rosed high density lipoprotein(< 0.9 mmol/L), and reduced TC/HDL-C 21. 8%, reduced apolipoprotein B 18%,too. It had no effect on blood sugar. CONCLUSION:Simvastatin is one of the safty and effective drugs to treat the senile type- I diabetics lipid metabolic disorder |
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| Keywords: | diabetes lipid metabolic disorder simvastatin |
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