Pathogenesis of bronchial obstruction under conditions of disturbed adrenoception

Experimental disturbances in β-adrenoception cause non-specific changes in the development of bronchial obstruction in response to humoral and neural bronchoconstrictor stimuli, which are manifested in bronchial smooth muscle hyperreactivity. The bronchospastic reaction develops more rapidly, persists for a longer time, and is always accompanied by early activation of non-smooth muscle pathogenetic mechanisms. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 3, pp. 275–277, March, 1999