心外科术后吗啡与芬太尼患者自控镇痛效果观察

目的观察吗啡和芬太尼患者自控镇痛 (PCIA)用于心外科术后疼痛康复的疗效和安全性。方法将 70例心脏手术患者随机分为吗啡组和芬太尼组 ,术后在ICU病房用PCIA进行疼痛康复 ,观察镇痛起效时间、效果及满意率 ,以及 2 4h、48h和 72h生命体征及恶心、呕吐等副作用。结果两组患者的镇痛效果及满意率无显著性差异 ,生命体征均平稳 ,但芬太尼组的起效时间明显短于吗啡组 (P <0 .0 5 ) ,患者的恶心、呕吐次数明显少于吗啡组 (P <0 .0 5 )。结论吗啡和芬太尼PCIA均能安全地用于心外科术后患者急性疼痛的康复治疗 ,但芬太尼PCIA明显比吗啡PCIA起效快 ,恶心、呕吐副作用少。

Effect of patient-controlled intravenous analgesia with morphine and fentanyl after cardiac surgery

ObjectiveTo observe the efficacy and safety of patient-controlled intravenous analgesia (PCIA) with morphine and fentanyl after cardiac surgery.MethodsSeventy patients operated with cardiac surgery were randomly divided into morphine group (group M) and fentanyl group (group F). The beginning efficacy time of analgesia,efficacy of analgesia,patient's evaluation,heart rate,respiratory rate,mean arterial pressure,and incidence of nausea and vomiting were assessed.ResultsThere were no significant differences in efficacy and patient's evaluation between two groups. In group G,the beginning efficacy time of analgesia was significantly shorter than those in group M ( P<0.05),and the times of nausea and vomiting were significant less than those in group M ( P<0.05).ConclusionPCIA with fentanyl and morphine for postoperative pain relief after cardiac surgery is efficient and safe. Compared with morphine,the beginning efficacy time of fentanyl is significant shorter,and times of nausea and vomiting are little.