参芎注射液对急性脑梗死患者血液流变学的影响

目的观察参芎注射液对脑梗死患者血液流变学和纤维蛋白原含量的影响。方法将72例急性脑梗死患者随机分为两组，参芎组（n=34）给予参芎注射液100ml，静脉滴注，2次／d；丹参组（n=38）给予丹参注射液20ml加入5％葡萄糖注射液100ml中，静脉滴注，2次／d。疗程14d。于治疗前后根据神经功能缺损程度（NDS）评分标准进行评分，并检测血液流变学及纤维蛋白原含量。结果参芎组的总有效率（88．2％）显著高于丹参组（73．7％）（P〈0．05）；参芎组治疗后全血粘度、血浆粘度、红细胞聚集指数、纤维蛋白原较治疗前显著改善（P〈0．05或P〈0．01）；丹参组治疗后仅全血粘度显著改善（P〈0．05）；两组治疗后比较，参芎组全血粘度（中切）、血浆粘度、纤维蛋白原显著低于丹参组（均P〈0．05）。结论参芎注射液治疗急性脑梗死效果明显，可能通过改善血液流变学、降低纤维蛋白原含量起到神经保护作用。

Effects of Shenxiong injection on the hemorheology in patients with acute cerebral infarction

Objective To observe the therapeutic effect of Shenxiong injection in the treatment of acute cerebral infarction and its influence on hemorheology and fibrinogen level. Methods 72 patients with acute cer-ebral infarction were randomly divided into two groups. 34 patients in Shenxiong injection group were treated with Shenxiong injection(100 ml, intravenously guttae, bid);38 patients in salvia mihiorrhiza injection group were treated with salvia mihiorrhiza(20 ml plus 100 ml parenteral solution, intravenously guttae, bid). All treat-ment lasted 14 days. NDS was introduced to evaluate the clinical efficiency. The indexes of hemorheology and fi-brinogen level in two groups was sampled before and after treatment. Results Total effctive rate in Shenxiong group(88.2%) was significantly higher than that in salvia mihiorrhiza group (73.7%) (P < 0.05) ; Compared with those before treatment, the indexes of hemorheology and fibrinogen content in Shenxiong group decreased significantly (P < 0.05, or P < 0.01) ; however, only indexes of whole blood viscosity (low and high shear rate) in salvia mihiorrhiza group decreased significantly after treatment (P < 0.05). After treatment, indexes of whole blood viscosity(moderate shear rate), plasma viscosity and fibrinogen content in Shenxiong group was signifi-cantly lower than that in salvia mihiorrhiza group (all P < 0.05). Conclusion Shenxiong injection may have neuroprotective effcts on acute cerebral infarction by improving the indexes of hemorheology and decreasing fi-brinogen content,which was better than the effect of salvia mihiorrhiza injection.