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Myocarditis of Mixed Connective Tissue Disease: Favourable Outcome after Intravenous Pulsed Cyclophosphamide |
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| Authors: | C. Hammann C. Y. Genton A. Delabays A. Bischoff Delaloye J. Bogousslavsky F. Spertini |
| Affiliation: | (1) Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, CH;(2) Department of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, CH;(3) Division of Cardiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, CH;(4) Division of Nuclear Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, CH;(5) Service of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, CH |
| Abstract: | A 30-year-old woman with mixed connective tissue disease was admitted with Wernicke’s aphasia and progressive dyspnoea with chest pain. Multiple brain infarcts on a computed tomographic scan were compatible with a thromboembolic aetiology. Echocardiography showed marked hypokinesia of the posterior wall, biventricular dilatation and a decreased left-ventricle ejection fraction (40%). A diagnosis of myocarditis was made on myocardial biopsies disclosing interstitial lymphocytic infiltrates and myocardial fibre necrosis. A treatment with steroids and monthly pulsed cyclophosphamide was introduced. The heart function rapidly improved as assessed by a left-ventricle ejection fraction of 55% and remained stable 17 months thereafter. Received: 10 November 1997 / Accepted: 22 June 1998 |
| Keywords: | :Cyclophosphamide – Heart failure – Mixed connective tissue disease – Myocarditis |
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