羟考酮复合丙泊酚在无痛取卵术中的应用

目的观察羟考酮复合丙泊酚用于无痛取卵术的镇痛效果及安全性。方法选择我院门诊行无痛取卵术患者100例,年龄20~40岁,体重45~75kg,ASAⅠ或Ⅱ级,按随机数字表法分为两组:羟考酮复合丙泊酚组(A组)和单纯丙泊酚组(B组),每组50例。A组缓慢静脉注射羟考酮0.1mg/kg(生理盐水稀释至5ml),B组静脉注射等量生理盐水,5min后均静脉注射丙泊酚1.5~2mg/kg。苏醒时间、手术操作时间、丙泊酚用量、术后30min VAS评分和不良反应发生情况。结果术中丙泊酚用量A组为(121±18)mg,明显少于B组的(165±21)mg(P0.05)。术后VAS评分A组为(1.5±0.8)分,明显低于B组的(3.2±0.7)分(P0.05)。体动反应A组有8例(16%),明显少于B组的30例(60%)(P0.05)。结论羟考酮复合丙泊酚可安全用于无痛取卵术并能减少丙泊酚用量,减轻术后疼痛。

Application of oxycodone hydrochloride combined with propofol in painless oocyte retrieval

Objective To investigate the effect and safety of oxycodone hydrochloride combined with propofol for patients underwent painless oocyte etrieval.Methods Patients who underwent pain-less oocyte retrieval 100 cases,falling into ASA grade Ⅰ or Ⅱ catergory,aged 20 to 40 years old, weighing 45-75 kg,were randomly divided into group A and group B,50 patients in each group,ac-cording to random number tables.Group A were injected slowly oxycodone hydrochloride 0.1 mg/kg (diluted to 5 ml of normal saline),and group B saline.All patients were injected propofol 1.5-2 mg/kg after 5 min.Recovery time,operation time,propofol consumption,post-operative 30 min VAS scores and side effects were recorded accordingly.Results The propofol consumption (121 ± 18)mg in group A was significantly less than that in group B (1 65 ±21)mg (P <0.05).The VAS scores (1.5±0.8)score in group A was lower than that in group B (3.2 ±0.7)score (P <0.05 ). The movement response occurred in 8 (1 6%)and 30 (60%)patients in group A and group B (P <0.05),respectively.Conclusion Oxycodone hydrochloride combined with propofol can be safely used for painless oocyte retrieval and reduce propofol consumption,relieving postoperative pain.