INFLUENCE OF EA ON ELECTROCARDIOGRAM AND MONOAMINE TRANSMITTER AND c-Fos OF BRAIN STEM OF ACUTE MYOCARDIAL ISCHEMIA IN RATS

Manystudleshaveconfirmedthattheeffectofacupuncturetreatmentforcoronaryheartdls-easeisobvious.Needlingatpointsofpericardi-ummeridian(PC)ofHandxJueyingmaystrengthentheleftventricularcontractility,in-creasethecardiacoutputandcoronaryoutflowtoimprovethemicrocirculationofmyocardium,andthusprotectthemyocardlumfrommoredamageduringrnyocardialischen1ia.[1'2]Basedonourpreviousworks,ourexperimentaimedtoinvestigatetheinfluenceofEAonECGandmonoamineneurotransmittersinbrainstemofratwithlSchemlcmyocardlal…

INFLUENCE OF EA ON ELECTROCARDIOGRAM AND MONOAMINE TRANSMITTER AND c-Fos OF BRAIN STEM OF ACUTE MYOCARDIAL ISCHEMIA IN RATS

The present study aimed at the investigation of the changes of electrocardiogram (ECG) and monoamine transmitters in brainstem of rats with acute myocardial ischemia (AMl) with electroacupuncture (EA) at Neiguan (PC 6) and Jianshi (PC 5) treated by means of physiologic and histofluorescent and immunofluorescent methods. The results are as follows: 1. EA couId prevent ST segrnent and T wave from elevating during acute myocardial ischemia (P < 0. 05 ). 2. Monoamine-containing neurons with clear figure and bright fluoreasence, pre-and terminal axons were seen in Iocus coeruleus,lateral horn of splnal cord in two groups by the high specific sensitivity histofluorescence technique.The reaction of fluorescence was stronger in EA group than that in control one. The serotonin (5-HT) immunoreactive (ir) cells appeared in nucleus raphe (B 1, B 2). The 5-HT ir grains were more intense in EA group than that in control group. Tyrosine hydrotylase (TH) immunoreactive (ir) cell bodies were found within confines of catecholaminergic nuclei (A 1, A 2 ) of medulla. The immunofluorescence was weaker in EA group than that in control one. The results suggest that EA may regulate acute myocardial ischemia through brain stem.