首页 | 本学科首页   官方微博 | 高级检索  
     


Single region of interest versus multislice T2* MRI approach for the quantification of hepatic iron overload
Authors:Meloni Antonella  Luciani Antongiulio  Positano Vincenzo  De Marchi Daniele  Valeri Gianluca  Restaino Gennaro  Cracolici Eliana  Caruso Vincenzo  Dell'amico Maria Chiara  Favilli Brunella  Lombardi Massimo  Pepe Alessia
Affiliation:Fondazione G.Monasterio CNR-Regione Toscana and Institute of Clinical Physiology, Pisa, Italy. antonella.meloni@ifc.cnr.it
Abstract:

Purpose

To evaluate the effectiveness of the single ROI approach for the detection of hepatic iron burden in thalassemia major (TM) patients in respect to a whole liver measurement.

Materials and Methods

Five transverse hepatic slices were acquired by a T2* gradient‐echo sequence in 101 TM patients and 20 healthy subjects. The T2* value was calculated in a single region of interest (ROI) defined in the medium‐hepatic slice. Moreover, the T2* value was extracted on each of the eight ROIs defined in the functionally independent segments. The mean hepatic T2* value was calculated.

Results

For patients, the mean T2* values over segments VII and VIII were significantly lower. This pattern was substantially preserved in the two groups identified considering the T2* normal cutoff. All segmental T2* values were correlated with the single ROI T2* value. After the application of a correction map based on T2* fluctuations in the healthy subjects, no significant differences were found in the segmental T2* values.

Conclusion

Hepatic T2* variations are low and due to artifacts and measurement variability. The single ROI approach can be adopted in the clinical arena, taking care to avoid the susceptibility artifacts, occurring mainly in segments VII and VIII. J. Magn. Reson. Imaging 2011;33:348–355. © 2011 Wiley‐Liss, Inc.
Keywords:multislice multiecho T2*  liver  thalassemia major  iron overload
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号