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| 1型糖尿病(T1D)的细胞免疫学发病机制的研究进展 | |
| 引用本文： | 李敏. 1型糖尿病(T1D)的细胞免疫学发病机制的研究进展[J]. 复旦学报(医学版), 2012, 39(5): 525-530. DOI: 10.3969/j.issn.1672 8467.2012.05.017 |
| 作者姓名： | 李敏 |
| 作者单位： | 复旦大学附属中山医院普外科 上海 200032 |
| 基金项目： | 复旦大学重点学科优秀博士生科研资助计划~~ |
| 摘 要： | 近年来,1型糖尿病(type 1 diabetes,T1D)的发病率不断上升,其发病是遗传、环境、免疫等因素共同作用引发了胰岛β细胞为主体的自身免疫损害反应。T1D的发病机制涉及免疫应答及调节等免疫过程,其中细胞免疫在T1D的发病过程中起着重要作用,CD4+及CD8+ T淋巴细胞的浸润,B淋巴细胞、自然杀伤细胞(natural killer cells,NK)、树突状细胞(dendritic cells,DC)等免疫细胞共同参与了β细胞的损伤,最终引起T1D的发病。 |
| 关 键 词： | 1型糖尿病(T1D) 自身免疫性疾病 T淋巴细胞 |
Advances in the cellular immunologic mechanism of pathogenesis of type 1 diabetes(T1D) |
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| LI Min. Advances in the cellular immunologic mechanism of pathogenesis of type 1 diabetes(T1D)[J]. Fudan University Journal of Medical Sciences, 2012, 39(5): 525-530. DOI: 10.3969/j.issn.1672 8467.2012.05.017 | |
| Authors: | LI Min |
| Affiliation: | Department of General Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China |
| Abstract: | In recent years,the incidence of type 1 diabetes(T1D) continues to increase.It is supposed that heredity,environmental and immune factors participate in the damage of pancreatic β cells and associated reaction of autoimmune damage.Both the immune regulation and immune response are involved in the pathogenesis of T1D,in which cellular immunity plays a significant role,the infiltration of CD4+ and CD8+ T lymphocyte,B lymphocytes,natural killer(NK) cells,dendritic cells(DC) and other immune cells take part in the damage of pancreatic β cells,which ultimately lead to T1D. |
| Keywords: | type 1 diabetes(T1D) autoimmune disease T lymphocyte |
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