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| RAD001对胃癌SGC7901细胞生长的抑制作用及分子机制 | |
| 引用本文： | 刘 磊,刘 莹,孔庆兖. RAD001对胃癌SGC7901细胞生长的抑制作用及分子机制[J]. 南京医科大学学报(自然科学版), 2011, 0(1): 31-36 |
| 作者姓名： | 刘 磊 刘 莹 孔庆兖 |
| 作者单位： | 徐州医学院病理教研室; |
| 基金项目： | 江苏省高校自然科学研究指导性计划项目(05KJD320234) |
| 摘 要： | 目的:研究mTOR特异性抑制剂RAD001对胃癌SGC7901细胞增殖的影响,并探讨survivin在其中的作用.方法:常规培养胃癌SGC7901细胞,RAD001单独或联合顺铂干预,MTT法测定RAD001对胃癌SGC7901细胞增殖的影响,流式细胞术检测细胞凋亡率.免疫细胞化学和Western-blot检测药物作用... |
| 关 键 词： | RAD001 survivin SGC7901细胞 |
The effect of RAD001 inhibiting cell growth of gastric cancer cells SGC7901 and its molecular mechanisms |
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| LIU Lei,LIU Ying and KONG Qin-yan. The effect of RAD001 inhibiting cell growth of gastric cancer cells SGC7901 and its molecular mechanisms[J]. Acta Universitatis Medicinalis Nanjing, 2011, 0(1): 31-36 | |
| Authors: | LIU Lei LIU Ying KONG Qin-yan |
| Affiliation: | LIU Lei,LIU Ying*,KONG Qin-yan(Department of Pathology,Xuzhou Medical College,Xuzhou 221002,China) |
| Abstract: | Objective: To investigate the role of mTOR specific inhibitor RAD001 in inhibiting gastric cancer cell SGC7901 prolif-eration and the possible mechanism of survivin in the inhibition.Methods:SGC7901 cells were cultivated,treated with RAD001 alone or in combination with cisplatin.MTT,flow cytometry,Immunocytochemistry and Western-blot array were used to investigate the cell proliferation,apoptosis and the expression of survivin in cells.Results:After treated with RAD001 alone or in combination with cisplatin... |
| Keywords: | RAD001 survivin SGC7901 cells |
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