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| 降钙素基因相关肽拮抗垂体后叶素引起心肌缺血性电生理改变的观察 | |
| 引用本文： | 裴建明,臧益明,朱妙章,牛国保,王跃民,李红梅,施溥涛. 降钙素基因相关肽拮抗垂体后叶素引起心肌缺血性电生理改变的观察[J]. 中国心脏起搏与心电生理杂志, 1995, 0(2) |
| 作者姓名： | 裴建明 臧益明 朱妙章 牛国保 王跃民 李红梅 施溥涛 |
| 作者单位： | 第四军医大学生理学教研室，解放军３２３医院，上海生物化学研究所 |
| 摘 要： | 用浮置微电极技术观察垂体后叶素（Ｐｉｔ）对兔心肌细胞的异常电生理学效应及降钙素基因相关肽（ＣＧＲＰ）的保护作用。结果表明：静脉注射Ｐｉｔ后，心率减慢，心外膜电图ＳＴ段抬高，Ｔ波倒置，心室肌细胞跨膜动作电位（ＴＭＰ）的静息电位（ＲＰ）及动作电位振幅（ＡＰＡ）明显降低（Ｐ均＜０．０１）。复极化至３０％、５０％和９０％的动作电位时程（ＡＰＤ３０、ＡＰＤ５０、ＡＰＤ９０）亦明显缩短（Ｐ均＜０．０５）。静脉注射Ｐｉｔ同时注射ＣＧＲＰ，可见ＣＧＲＰ明显拮抗以上异常改变，从而起到保护心肌和稳定心肌的电生理作用。 |
| 关 键 词： | 降钙素基因相关肽，垂体后叶素，心肌电生理，心外膜电图，心肌缺血 |
The Observation of Antagonistic Effect of Calcitonin Gene-Related Peptide on the Changes of Ischemic Myocardial Electrophysiology Induced by Pituitrin |
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| Pei Jianming,Zang Yimin,Zhu Miaozhang,et al. The Observation of Antagonistic Effect of Calcitonin Gene-Related Peptide on the Changes of Ischemic Myocardial Electrophysiology Induced by Pituitrin[J]. Chinese Journal of Cardiac Pacing and Electrophysiology, 1995, 0(2) | |
| Authors: | Pei Jianming Zang Yimin Zhu Miaozhang et al |
| Abstract: | The abnormal myocardial electrophysiological changes of Pituitrin and protective effects of Calcitonin gene-related peptide(CGRP)were observed with floating microelectrode technique in rabbit heart.After Pituitrin administered intravenously, heart rate(HR)slowed,ST segment of epicardial electrogram(EEG) elevated with a reverse of T wave and resting potential(RP),action potential amplitude (APA)decreased obviously(P<0.01),also the action potential duration(APD30,APD50,APD90) shortened significantly(P<0.05).But with the simultaneous administration of Pituitrin and CGRP,the above abnomal changes were obviously alleviated.These results indicated that Putuitrin could induce the changes of ischemic myocardial electrophysiology and CGRP might develop the stabilizing and protective effects on the ischemic myocardial electrophysiology. |
| Keywords: | Calcitonin gene-related peptide Pituitrin Myocardial electrophysiology Epicardial electrogram Myocardial ischemia |
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