宫颈感染与体外受精-胚胎移植及自然妊娠先兆流产的相关性研究

【目的】探讨孕妇宫颈感染与体外受精-胚胎移植（IVE-ET）及自然妊娠先兆流产的相关性。【方法】选择2013年3月至2014年1月本院就诊的 IVF-ET术后出现先兆流产的患者37例作为研究组，同期随机抽取自然怀孕先兆流产40例作为对照组。所有研究对象皆行宫颈分泌物培养（厌氧菌，支原体，细菌培养），比较两者宫颈感染情况。【结果】研究组宫颈分泌物培养阳性率为67．57％（25/37）；对照组为27．50％（11/40），研究组明显高于对照组，且两组阳性率比较差异有显著性（χ2＝17．839，P＜0．05）。两组宫颈感染阳性与阴性者之间TNF-α水平比较，差异有显著性（t＝23．678、27．340，P ＜0．05）。但两组阳性与阴性者分别比较，差异无显著性（t＝1．241、1．352，P＞0．05）。【结论】先兆流产的患者与宫颈感染存在相关性，且 IVF-ET比自然妊娠更易感染，在先兆流产治疗中应常规行宫颈分泌物培养，以提高保胎成功率。

Study of the Correlation of Cervical Infection with IVF-ET and Natural Pregnancy Threatened A-bortion

[Obj ective]To explore the correlation of cervical infection with in vitro fertilization-embryo transfer （IVF-ET）and natural pregnancy threatened abortion.[Methods]A total of 3 7 patients with threatened abortion after IVF-ET in our hospital from July 2012 to July 2013 were chosen as the study group.Concurrent 40 patients with natural pregnancy threatened abortion were randomly chosen as the control group.Cervical secretion culture （anaerobic bacteria,mycoplasma and bacteria）was performed in all patients.Cervical infection was compared be-tween them.[Results]The positive rate of cervical secretions in the study group and control group was 67.57%and 27.50% respectively,and that in the study group was obviously higher than that in control group,and there was significant difference in the positive rate between two groups（χ2=17.839,P〈0.05）.There was significant difference in the level of TNF-αbetween patients with positive and negative cervical infection of two groups（t=23.678,27.340,P〈0.05）.But there was no significant difference between two groups（t=1.241,1.352,P＆gt;0.05）.[Conclusion]There is correlation between patients with threatened abortion and cervical infection,but pa-tients with IVF-ET is more easy to be infected.Routine cervical secretion culture in the treatment of threatened a-bortion should be taken so as to increase the success rate of pregnancy.