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| 酒精对大鼠肝脏脂质过氧化的影响 | |
| 引用本文： | 杨成峰 陈学敏. 酒精对大鼠肝脏脂质过氧化的影响[J]. 现代预防医学, 1996, 23(3): 141-143 |
| 作者姓名： | 杨成峰 陈学敏 |
| 作者单位： | 同济医科大学环境卫生学教研室 |
| 摘 要： | 采用体外和体内实验研究了酒精对大鼠肝脏脂质过氧化的影响。结果表明酒精在体外和体内均可使大鼠肝匀浆和线粒体脂质过氧化物（ＬＰＯ）含量显著增加，还原型谷胱甘肽（ＧＳＨ）含量显著降低（Ｐ＜０．０５）。体内研究还发现酒精可使大鼠肝脏和线粒体谷胱甘肽过氧化物酶（ＧＳＨ—Ｐｘ）活性显著降低（Ｐ＜０．０５），但对肝脏和线粒体超氧化物岐化酶（ＳＯＤ）活性则没有明显影响（Ｐ＞０．０５）。本研究进一步证实酒精具有显著的致肝脏脂质过氧化作用。 |
| 关 键 词： | 酒精 肝脏 脂质过氧化 还原型谷胱甘肽 谷胱甘肽过氧化物酶 超氧化物岐化酶 |
STUDY ON THE EFFECT OF ALCOHOL ON LIVER LIPID PEROXIDATION IN RATS. |
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| Yang Chengfeng,et al.. STUDY ON THE EFFECT OF ALCOHOL ON LIVER LIPID PEROXIDATION IN RATS.[J]. Modern Preventive Medicine, 1996, 23(3): 141-143 | |
| Authors: | Yang Chengfeng et al. |
| Affiliation: | Yang Chengfeng,et al.Department of Environmental Health,Tongji Medical University,Wuhan 430030 |
| Abstract: | The effect of alcohol on liver lipid peroxidatin in rat was studied in vitro and in vivo. The results showed that alcohol caused the content of lipid peroxides(LPO) in rat liver homogenate and mitochondria to increase and caused the content of liver glutathione(GSH) to decrease significantly in vitro and in vivo.Compared with the control group,the activity of glutathione peroxidase(GSH-P x) in rat liver and mitochondria was reduced significantly in the alcohol group in vivo, but the activity of superoxide dismutase(SOD) in rat liver and mitochondria was not significantly affected in the alcohol group. |
| Keywords: | AlcoholLiverLipid peroxidationGlutathioneGlutathione peroxidaseSuperoxide dismutase |
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