| 趋化因子受体CX3CR1基因多态性与扩张型心肌病相关性研究 |
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| 引用本文： | 何星球,王艳云,周斌,饶莉. 趋化因子受体CX3CR1基因多态性与扩张型心肌病相关性研究[J]. 四川大学学报(医学版), 2010, 41(2) |
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| 作者姓名： | 何星球 王艳云 周斌 饶莉 |
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| 作者单位： | 四川大学华西医院,心内科,成都,610041;四川大学,分子与转化医学实验室,成都,610041 |
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| 基金项目： | 国家自然科学基金,四川省学术与技术带头人培养基金 |
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| 摘 要： | 目的 研究扩张型心肌病(DCM)与趋化因子受体CX3CR1基因多态性的相关性,探讨DCM患者的遗传学发病机制.方法 采用聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP)方法测定211例DCM患者和211例正常对照者CX3CR1基因rs3732378(V249I)和rs3732379(T280M)位点的单核苷酸多态性,比较DCM组与对照组之间在基因型频率、等位基因频率方面差异有无统计学意义.结果 CX3CR1基因rs3732378和rs3732379位点基因型、等位基因频率在DCM组与正常对照组之间差异均无统计学意义.结论 本研究未发现CX3CR1基因rs3732378和rs3732379位点多态性与DCM相关.
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| 关 键 词： | Fractalkine CX3CR1 多态性 扩张型心肌病 |
CX3CR1 Polymorphism in Patients with Dilated Cardiomyopathy |
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| HE Xing-qiu,WANG Yan-yun,ZHOU Bin,RAO Li. CX3CR1 Polymorphism in Patients with Dilated Cardiomyopathy[J]. Journal of Sichuan University. Medical science edition, 2010, 41(2) |
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| Authors: | HE Xing-qiu WANG Yan-yun ZHOU Bin RAO Li |
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| Abstract: | Objective To investigate the association between CX3CR1 gene polymorphism and dilated cardiomyopathy (DCM). Methods Two single nucleotide polymorphisms (SNP) rs3732378(V249I) and rs3732379(T280M) in CX3CR1 gene were determined using PCR-RFLP. The frequencies of genotype and allele of these two SNPs were compared between 211 DCM patients and 211 normal controls. Results The genotype distribution of these two SNPs had no deviation from Hardy-Weinberg equilibrium either in DCM patients or in the controls. No significant difference was found in the frequencies of genotype and allele in rs3732378 and rs3732379 between the DCM patients and the controls. Conclusion CX3CR1 gene polymorphism is not associated with DCM. |
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| Keywords: | Fractalkine CX3CR1 Fractalkine CX3CR1 Polymorphism Dilated Cardiomyopathy |
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