| FAP-1和RAC-1在肝细胞性肝癌中的表达及其临床意义 |
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| 引用本文： | 董朝富,易继林,李兴睿,刘谨文,沈文状,符常波,万亚峰. FAP-1和RAC-1在肝细胞性肝癌中的表达及其临床意义[J]. 临床外科杂志, 2007, 15(12): 819-821 |
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| 作者姓名： | 董朝富 易继林 李兴睿 刘谨文 沈文状 符常波 万亚峰 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院普外科,武汉,430030;华中科技大学同济医学院附属同济医院普外科,武汉,430030;华中科技大学同济医学院附属同济医院普外科,武汉,430030;华中科技大学同济医学院附属同济医院普外科,武汉,430030;华中科技大学同济医学院附属同济医院普外科,武汉,430030;华中科技大学同济医学院附属同济医院普外科,武汉,430030;华中科技大学同济医学院附属同济医院普外科,武汉,430030 |
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| 摘 要： | 目的探讨RAC-1和FAP-1在肝细胞性肝癌(HCC)中的表达及其与肝癌浸润转移之间的关系。方法应用免疫组化SP技术,检测50例肝癌组织中RAC-1和FAP-1的表达,分析其与肝癌侵袭转移之间的关系。结果50例肝癌组织中RAC-1和FAP-1的表达与HCC的Edmondson分级、侵袭转移能力密切相关,而与患者性别、年龄、肿瘤大小无关;RAC-1和FAP-1的表达具有高度协同性。结论RAC-1和FAP-1的表达能反映HCC的侵袭转移能力,联合检测两种蛋白在肿瘤组织中的表达,可以更准确判断HCC的恶性程度和生物学行为。
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| 关 键 词： | 肝细胞性肝癌 RAC-1 FAP-1 肿瘤转移 |
| 文章编号： | 1005-6483（2007）12-0819-03 |
| 收稿时间： | 2007-07-25 |
| 修稿时间： | 2007-07-25 |
The expression of RAC-1 and FAP-1 in hepatocellular carcinoma and its clinical significance |
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| DONG Chao-fu , YI Ji-lin , LI Xing-rui , et al ,. The expression of RAC-1 and FAP-1 in hepatocellular carcinoma and its clinical significance[J]. Journal of Clinical Surgery, 2007, 15(12): 819-821 |
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| Authors: | DONG Chao-fu YI Ji-lin LI Xing-rui et al |
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| Abstract: | Objective To investigate the relationship between the expression of RAC-1 and FAP-1 in hepatocellular carcinoma(HCC)and metastasis characters of HCC.Methods Immunohistochemistry was used to detect the expression of RAC-1 and FAP-1 in primary tumor tissue of 50 cases of HCC and the results were analyzed in combination with the metastasis characters of HCC.Results The expression of RAC-1 and FAP-1 in HCC had a close relation with Edmondson grade and metastasis potential of tumor,but had no correlation with size of tumor and sex,age of the patients.Conclusion The expression of RAC-1 and FAP-1 in HCC may reflect the metastasis characters of HCC and combined detection of RAC-1 and FAP-1 in HCC may provide a more accurate parameter to judge the malignant degree and biological behaviors of HCC. |
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| Keywords: | hepatocellular carcinoma RAC-1 FAP-1 tumor metastasis |
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