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| 辛伐他汀对急性冠状动脉综合征患者血清妊娠相关蛋白-A和高敏C-反应蛋白的影响 | |
| 引用本文： | 可海霞,贾银明,王淑红,金培印,韩勤甫,唐兆斌. 辛伐他汀对急性冠状动脉综合征患者血清妊娠相关蛋白-A和高敏C-反应蛋白的影响[J]. 新乡医学院学报, 2010, 27(1) |
| 作者姓名： | 可海霞 贾银明 王淑红 金培印 韩勤甫 唐兆斌 |
| 作者单位： | 1. 安阳市人民医院急救中心,河南,安阳,455000 2. 安阳市人民医院心内科,河南,安阳,455000 |
| 摘 要： | 目的探讨辛伐他汀对急性冠状动脉综合征(ACS)患者血清妊娠相关蛋白-A(PAPP-A)和高敏C-反应蛋白(hs-CRP)的影响。方法ACS患者80例,随机分为辛伐他汀组(40例,常规治疗加辛伐他汀)和对照组(40例,常规治疗),治疗前和治疗1周后分别测定2组治疗前后外周血PAPP-A、hs-CRP水平,采用酶联免疫吸附法检测PAPP-A,散射比浊法检测hs-CRP。结果治疗前2组ACS患者血清PAPF-A、hs-CRP水平比较差别无统计学意义(P>0.05);与治疗前比较,治疗后辛伐他汀组和对照组PAPP-A和hs-CRP水平降低,差别均有统计学意义(P<0.01,P<0.05);治疗后辛伐他汀组患者血清PAPP-A和hs-CRP水平均明显低于对照组,差别有统计学意义(P<0.05)。结论辛伐他汀可降低ACS患者血清PAPP-A、hs-CRP水平,其稳定斑块的作用可能与抑制这些炎症因子的作用密切相关。 |
| 关 键 词： | 急性冠状动脉综合征 妊娠相关蛋白-A 辛伐他汀 高敏C-反应蛋白 |
Effect of Simvastatin on pregnancy-associated plasma protein-A and high sensitive C-reactive protein in patients with acute coronary syndrome |
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| KE Hai-xia,JIA Yin-ming,WANG Shu-hong,JIN Pei-yin,HAN Qin-fu,TANG Zhao-bin. Effect of Simvastatin on pregnancy-associated plasma protein-A and high sensitive C-reactive protein in patients with acute coronary syndrome[J]. Journal of Xinxiang Medical College, 2010, 27(1) | |
| Authors: | KE Hai-xia JIA Yin-ming WANG Shu-hong JIN Pei-yin HAN Qin-fu TANG Zhao-bin |
| Abstract: | Objective To explore the effect of Simvastatin on pregnancy-associated plasma protein-A(PAPP-A) and the high sensitive C-reactive protein(hs-CRP) in patients with acute coronary sydrome(ACS).Methods Eighty patients with ACS were randomly divided into Simvastatin group(n = 40,conventional therapy plus Simvastatin) and control group(n = 40, conventional therapy).The levels of PAPP-A were detected by enzyme-linked immune sorbent assay(ELISA) and hs-CRP levels were detected by scatter turbidimetry method before... |
| Keywords: | acute coronary sydrome pregnancy-associated plasma protein-A Simvastatin high sensitivity C-reactive protein |
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