CD44及CK18在卵巢浆液性癌中的表达及临床意义

目的:研究卵巢浆液性癌中CD44及CK18的表达及预后意义。方法:免疫组化法检测CD44及CK18蛋白在72例卵巢浆液性癌组织中的表达水平,分析其表达水平与卵巢癌临床病理指标的相关性。结果:CD44及CK18的阳性表达率分别为66.7%及100%。CD44阳性的肿瘤细胞呈团簇状分布于肿瘤组织中,这种表达模式在高级别浆液性癌中更明显。CK18表达与患者年龄、淋巴结转移有关(P分别为0.014及0.015);CD44、CK18表达与化疗效果、总生存期及无病生存期无关。卵巢浆液性癌中CD44、CK18表达无相关性。结论:CD44及CK18蛋白在卵巢浆液性癌组织中的表达能在一定程度上反映患者的预后,但与化疗效果及生存期无关。

The expressions and clinical significances of CD44 and CK18 in ovarian serous carcino-ma

Objective:To investigate the expression pattern and prognostic values of CD44 and CK18 in ovarian serous carcinoma. Methods:Immunohistochemical evaluation inclu-ding CD44 and CK18 was performed in paraffin wax-embedded tissues of 72 cases of ovarian se-rous carcinoma. The expression and the relationship with clinical parameters of these markers were analyzed. Results:The positive rates were 66. 7% for CD44 and 100% for CK18. Clusters of CD44+cells scattered in tumor tissue,and the expression pattern was more prominent in high-grade serous carcinoma. CK18 expression significantly correlated with age (P=0. 014) and lymph node metastasis ( P=0 . 015 ) . CD44 and CK18 expression levels neither were correlated with chemotherapeutic effects and overall disease free survival time,nor showed any mutual re-lationship between each other. Conclusion:The expressions of CD44 and CK18 are correlate with the prognosis of ovarian serous carcinoma,but they are not satisfactory indicators for che-motherapeutic effects and survival time.