黄芪对慢性肾炎非肾衰竭期患者血清NO的影响

目的:探讨黄芪对慢性肾炎非肾衰竭期患者血清NO的影响.方法:应用化学比色法,测定31例正常人及92例慢性肾炎非肾衰竭期患者的血清NO水平,并观察黄芪治疗前后NO的变化.结果:1.患者组血清NO水平较对照组明显降低;且随肾功能损害加重,血清NO水平有逐渐下降趋势.2.与常规治疗组比较,黄芪治疗后,患者血清NO水平显著升高,尿蛋白显著降低,但肾功能无显著变化.结论:慢性肾炎非肾衰竭期患者体内NO合成及释放不足,黄芪可促进NO合成增加,减少尿蛋白.

The effect of Astragalus membranaceus on serum NO in patients with chronic glomerulonephritis at pre-renal failure phase

Objective:To observe the effect of Astragalus membranaceus on serum NO in patients with chronic glomerulonephritis at pre-renal failure phase.Methods:The levels of serum NO 3 -/NO 2 - that can indirectly reflect serum nitric oxide were measured in 92 cases of chronic glomerulonephritis (CGN) at pre-renal failure phase and 31 normal subjects by chemical colorimetry.Renal function,serum NO and urinary protein of patients were examined before and after treatment with or without Astragalus membranaceus.Results:1.The levels of serum NO 3 -/NO 2 - in patients were significantly lower than those in the control group,with the lesions of renal function aggravating,the levels of serum NO 3 -/NO 2 - decreasing gradually.2.Astragalus membranaceus could remarkably increase serum NO 3 -/NO 2 - and decrease urinary protein.Conclusion:In patients with chronic glomerulonephritis at pre-renal failure phase,NO is insufficiednt.Astragalus membranaceus may contribute to the synthesis of NO and the decrease in urinary protein excretion.