Prevalence of major depressive disorder in patients receiving beta-blocker therapy versus other medications |
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| Authors: | R M Carney M W Rich A teVelde J Saini K Clark K E Freedland |
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| Affiliation: | 1. Michigan State University College of Human Medicine, East Lansing, MI, United States;2. Section of Emergency Medicine, Department of Internal Medicine, Michigan State University College of Osteopathic Medicine, Sparrow Health System, Lansing, MI, United States;3. Department of Emergency Medicine, Michigan State University College of Human Medicine, Sparrow Health System, Lansing, MI, United States;1. Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT;2. Center for Outcomes Research and Evaluation, Yale New Haven Health Services Corporation, New Haven, CT;3. Department of Health Administration and Policy, University of New Haven, West Haven, CT;1. Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan;2. Department of Biostatistics, Tsukuba Clinical Research & Development Organization, University of Tsukuba, Tsukuba, Japan;3. Department of Biostatistics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan;4. Johns Hopkins Medical Institutions, Baltimore, MD, USA |
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| Abstract: | ![]()
Depression is believed to be a common side effect in patients receiving beta-blocker therapy. However, diagnoses of depression defined by current diagnostic criteria may not be more common in patients receiving beta-blockers than in patients with the same medical disorder receiving other medications. Seventy-seven patients undergoing elective cardiac catheterization for evaluation of chest pain received a semi-structured diagnostic psychiatric interview. Twenty-one percent of the patients receiving beta-blockers and 33 percent of the patients receiving medications other than beta-blockers met the current American Psychiatric Association criteria for major depressive disorder (DSM-III) (p = NS). The mean heart rate and state anxiety scores for patients taking beta-blockers were significantly lower than those measured in patients taking medications other than beta-blockers. No other medical or demographic differences were observed between the two groups. Despite the methodologic limitations of the study, there does not appear to be a difference in the point prevalence of depression between patients receiving beta-blockers and those receiving other medications. |
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