神经重症患者静脉血栓栓塞的发生率、危险因素及住院结局分析

目的 探讨神经重症患者静脉血栓栓塞(venous thromboembolism,VTE)的发生率,并分析VTE相关的危险因素及其对住院结局的影响.方法 基于电子病历系统数据回顾性分析2019年10月-2020年9月首都医科大学附属北京天坛医院的神经重症患者,根据患者住ICU期间是否发生VTE分为VTE组和无VTE组,...

Incidence,Risk Factors and In-hospital Outcome of Venous Thromboembolism in Neurocritical Patients

Objective To explore the incidence and risk factors of venous thromboembolism (VTE) inneurocritical patients, and the influence of VTE on in-hospital outcomes.Methods The data of the neurocritical patients in Beijing Tiantan Hospital from October 2019 toSeptember 2020 were retrospectively analyzed. According to the presence of VTE or not after SAHduring ICU hospitalization, the patients were divided into VTE group and non-VTE group. Theincidence of VTE was calculated. The differences in mortality, the length of ICU stay and hospitalstay, and the cost of hospitalization were compared between the two groups. Multivariate logisticregression analysis was used to identify the risk factors of VTE in neurocritical patients.Results A total of 723 patients were included in this study, with a median age of 52 years old and383 males (53.0%), and 330 patients (45.6%) had VTE. Multivariate logistic regression analysisshowed that the age (OR 1.078, 95%CI 1.053-1.104), BMI (OR 1.082, 95%CI 1.013-1.156), andD-dimer level (OR 1.042, 95%CI 1.006-1.079) were independent risk factors for VTE. The inhospitalmortality between the two groups had no statistical difference (4.8% vs 3.6%, P =0.388).However, compared with non-VTE group, the length of hospital stay (21 d vs 18 d), the length ofICU stay (8 d vs 5 d) and the cost of hospitalization (121 358 CNY vs 93 717 CNY) increased in