早期系统化康复干预对急性缺血性卒中患者吞咽功能障碍及神经营养指标的影响研究

目的 分析早期系统化康复干预对急性缺血性卒中患者吞咽功能障碍、血清白蛋白(serum albumin,ALB)、血清前清蛋白(serum fraction prealbumin,PA)、血红蛋白(hemoglobin,Hb)、神经生长因子(nerve growth factor,NGF)及血清脑源性神经营养因子(bra...

Effect of Early Systematic Rehabilitation Intervention on Dysphagia and Neurotrophy in Patients with Acute Ischemic Stroke

Objective To analyze the early systematic rehabilitation intervention on swallowing dysfunction,serum albumin (ALB), serum fraction prealbumin (PA), hemoglobin (Hb), nerve growth factor(NGF) and serum brain-derived neurotrophic factor (BDNF) in patients with acute ischemic stroke(AIS).Methods AIS patients admitted to Beijing Tongren Hospital of Capital Medical Universityfrom January 2017 to January 2019 were included in this study, and all the patients wererandomly divided into the control group and observation group. The control group receivedroutine rehabilitation intervention, the observation group received early systematic rehabilitationintervention, and the treatment time was 3 months for both groups. The changes of NIHSS score,motor function, neurotrophic indicators (ALB, PA, Hb, NGF, BDNF) level, swallowing dysfunctionimprovement (water swallow test) of the two groups were compared before and after intervention.Results Finally, A total of 80 patients were included, with 40 in control group and 40 in treatment group. After the 3-month intervention, all the indicators improved in the observation groupcompared to the control group (control vs observation for all the following indicators): NIHSSscore (4.59±1.98 points vs 4.14±1.73 points, P =0.027), ALB (34.13±5.01 g/L vs 38.76±5.73 g/L, P <0.001), PA (241.56±30.21 mg/L vs 279.63±35.47 mg/L, P <0.001), Hb (131.57±16.42 g/L vs140.38±18.36 g/L, P <0.001), NGF (54.28±6.39 pg/mL vs 68.73±8.92 pg/mL, P <0.001), BDNF(5.84±0.62 ng/mL vs 7.98±0.95 ng/mL, P <0.001) and the Fugl-Meyer score (50.17±16.48 pointsvs 72.28±22.39 points, P <0.001). The improvement rate of swallowing dysfunction in observationgroup was also higher than that in control group (95.0% vs 80.0%, P =0.001).Conclusions Early systematic rehabilitation intervention can effectively improve the AIS patient'sneurotrophic condition and swallowing function.