青年缺血性卒中患者脑小血管病总负荷的危险因素分析

目的 探讨青年缺血性卒中患者脑小血管病(cerebral small vessel disease,CSVD)总负荷的危险因素.方法 回顾性纳入2016年1月-2020年10月于首都医科大学附属北京朝阳医院神经内科连续收治的青年急性缺血性卒中患者.通过MRI评估腔隙、脑白质高信号、扩大的血管周围间隙及脑微出血四种CSV...

Analysis on Risk Factors for Total Cerebral Small Vessel Disease Burden in Young Patients with Ischemic Stroke

Objective To explore the risk factors for the total cerebral small vessel disease (CSVD) burden inyoung patients with ischemic stroke.Methods From January 2016 to October 2020, the clinical and imaging data of young patientswith acute ischemic stroke hospitalized in Department of Neurology of Beijing Chaoyang Hospital,Capital Medical University, were retrospectively analyzed. The total score of CSVD of all thepatients were evaluated by assessing the four imaging markers of CSVD, including lacune, whitematter hyperintensity, enlarged perivascular space and cerebral microbleed. According to the totalscore, these patients were divided into four groups of 0 point, 1 point, 2 points, and 3-4 points,respectively. Ordinal logistic regression analysis was used to identify the risk factors for the totalCSVD burden in young patients with ischemic stroke.Results A total of 272 patients were enrolled, with the average age of 39.55±5.19 years and 230males (84.6%), including 146 (53.7%) in 0 score group, 71 (26.1%) in 1 score group, 40 (14.7%)in 2 score group and 15 (5.5%) in 3-4 score group. Univariate analysis showed that there werestatistical differences in age, hypertension and creatinine among the four groups. Ordinal logisticregression analysis showed that the aging (OR 1.110, 95%CI 1.048-1.175) and hypertension (OR2.649, 95%CI 1.537-4.559) were independently associated with the total CSVD burden.Conclusions The increasing age and hypertension were independent risk factors for the totalCSVD burden in young patients with ischemic stroke.