|
|||||
|
|
| NF1相关神经纤维瘤炎症微环境的研究进展 | |
| 引用本文： | 游元和,王延安. NF1相关神经纤维瘤炎症微环境的研究进展[J]. 中国口腔颌面外科杂志, 2021, 19(4): 376-379. DOI: 10.19438/j.cjoms.2021.04.018 |
| 作者姓名： | 游元和 王延安 |
| 作者单位： | 上海交通大学医学院附属第九人民医院 口腔颌面-头颈肿瘤科,上海交通大学口腔医学院, 国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海 200011 |
| 摘 要： | [提要]神经纤维瘤是I型神经纤维瘤病的特征性症状之一,终生进展,治疗难度大,而其发病机制仍不明确.瘤内的施万细胞呈NF1双等位基因失活状态,可激活RAS-GTP信号转导,继而释放大量细胞因子,为免疫细胞的募集提供了富含细胞因子的微环境.相较于免疫炎症细胞在正常外周神经中的低占比率,在NF1相关神经纤维瘤中,30％的细胞... |
| 关 键 词： | I型神经纤维瘤病 神经纤维瘤 肥大细胞 巨噬细胞 肿瘤炎症微环境 |
| 收稿时间： | 2020-11-18 |
| 修稿时间： | 2021-02-01 |
Research progress of inflammatory microenvironment in NF1 related neurofibroma |
|
| YOU Yuan-he,WANG Yan-an. Research progress of inflammatory microenvironment in NF1 related neurofibroma[J]. China Journal of Oral and Maxillofacial Surgery, 2021, 19(4): 376-379. DOI: 10.19438/j.cjoms.2021.04.018 | |
| Authors: | YOU Yuan-he WANG Yan-an |
| Affiliation: | Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology. Shanghai 200011, China |
| Abstract: | Neurofibroma is one of the characteristic lesions of neurofibromatosis type 1. However, the pathogenesis of neurofibromas is still not completely known. The highly active RAS-GTP signal transduction of Schwann cells with biallelic inactivation can produce a large number of cytokines, which provides a cytokine-rich microenvironment for immune cell recruitment. In normal peripheral nerves, the proportion of immune inflammatory cells is not high. In NF1-related neurofibromas, 30% of the cells are monocytes/macrophages. Mast cells, T cells and dendritic cells (DC) also present. Increased evidences indicate that there is a correlation between inflammation and tumorigenesis. This review summarized the research progress of inflammatory cells in the microenvironment of NF1-related neurofibroma. |
| Keywords: | Neurofibromatosis type 1 Neurofibroma Mast cell Macrophage Tumor inflammatory microenvironment |
| 点击此处可从《中国口腔颌面外科杂志》浏览原始摘要信息 | |
| 点击此处可从《中国口腔颌面外科杂志》下载全文 | |