正电子类药物全自动核素分装仪的研究进展

近年来，我国核医学事业飞速发展，放射性核素被广泛地应用于肿瘤、心脏疾病和神经疾病的诊疗中。正电子类药物分装是核医学诊疗前的必要步骤。由于手工分装会对核医学工作者造成一定的核辐射以及产生抽取剂量准确性等问题，因此研制全自动核素分装仪具有重要的临床价值。笔者系统回顾了全自动核素分装仪的发展历程，重点阐述现有产品在核素分装、原液稀释、气泡检测方面的功能，并提出现有产品存在的维护困难、价格昂贵、功能不完善等不足，最后对正电子类药物全自动核素分装仪在核素注射、核素剂量计算、功能模块化等未来发展方向上的应用进行了展望。

Research progress of positron radiopharmaceutical automatic nuclide packing instrument

In recent years, with the rapid development of nuclear medicine in China, radionuclides have been widely used in the diagnosis and treatment of tumors, heart diseases, and neurodegenerative diseases. Positron radiopharmaceutical nuclide packing is a necessary step before diagnosis and treatment can be performed in nuclear medicine clinics. Given that the process of manual packing would expose nuclear medicine workers to nuclear radiation, the development of an automatic nuclide packing instrument is of great clinical value. The development process of the automatic nuclide packaging instruments was reviewed; the functions of existing products, including nuclide packing, stock solution dilution, and bubble detection, were demonstrated; and problems in existing products, including maintaining difficulties, expensive costs, and insufficient functions, were identified. Finally, this paper discussed the prospects for the future development directions of nuclide packing, such as combining nuclide injection, nuclide quantity calculation, functional modularization, and others.