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| Stathmin表达与局部晚期口腔鳞癌患者TPF诱导化疗远期疗效的相关性分析 | |
| 引用本文： | 谈亦然,赵铜超,王丽珍,李江,琚梧桐,朱东旺,张志愿,钟来平. Stathmin表达与局部晚期口腔鳞癌患者TPF诱导化疗远期疗效的相关性分析[J]. 中国口腔颌面外科杂志, 2021, 19(3): 217-221. DOI: 10.19438/j.cjoms.2021.03.006 |
| 作者姓名： | 谈亦然 赵铜超 王丽珍 李江 琚梧桐 朱东旺 张志愿 钟来平 |
| 作者单位： | 1.上海交通大学医学院附属第九人民医院 口腔颌面-头颈肿瘤科, 2.口腔病理科,上海交通大学口腔医 学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海 200011 |
| 基金项目： | 国家自然科学基金（81972525、81672660）; 上海市卫生健康委员会学科带头人计划（2018BR41）; 上海交通大学医学院附属第九人民医院临床研究型MDT项目（201916） |
| 摘 要： | 目的:验证微管解聚蛋白(Stathmin)能否预测口腔鳞癌(oral squamous cell carcinoma,OSCC)患者从多西紫杉醇、顺铂、5氟尿嘧啶(TPF)诱导化疗中远期获益.方法:收集2008年3月-2010年12月入组TPF诱导化疗临床试验的256例OSCC患者的远期随访结果.收集患者肿瘤活检标本,... |
| 关 键 词： | 口腔鳞癌 微管解聚蛋白 诱导化疗 预后 |
| 收稿时间： | 2020-12-07 |
| 修稿时间： | 2021-03-11 |
Stathmin expression correlated with the long-term survival benefit from TPF induction chemotherapy in patients with locally advanced oral squamous cell carcinoma |
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| TAN Yi-ran,ZHAO Tong-chao,WANG Li-zhen,LI Jiang,JU Wu-tong,ZHU Dong-wang,ZHANG Zhi-yuan,ZHONG Lai-ping. Stathmin expression correlated with the long-term survival benefit from TPF induction chemotherapy in patients with locally advanced oral squamous cell carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2021, 19(3): 217-221. DOI: 10.19438/j.cjoms.2021.03.006 | |
| Authors: | TAN Yi-ran ZHAO Tong-chao WANG Li-zhen LI Jiang JU Wu-tong ZHU Dong-wang ZHANG Zhi-yuan ZHONG Lai-ping |
| Affiliation: | 1. Department of Oromaxillofacial Head and Neck Oncology, 2. Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology. Shanghai 200011, China |
| Abstract: | PURPOSE: This study analyzed the role of Stathmin as a predictive biomarker on the long-term benefit of TPF induction chemotherapy based on a 11-year follow-up results. METHODS: Long-term follow-up results of 256 oral squamous cell carcinoma (OSCC) patients enrolled in the TPF induction chemotherapy trial were collected. Tumor biopsy specimens were collected for Stathmin immunohistochemical staining and scoring. Subgroup prognosis was analyzed according to the Stathmin expression. Stathmin and other baseline characteristics were analyzed by univariate, multivariate, and Cox regression model with SPSS 13.0 software package. RESULTS: Stathmin expression predicted the response of TPF induction chemotherapy in OSCC patients. OSCC patients with lower Stathmin expression benefited from TPF induction chemotherapy, while OSCC patients with higher Stathmin expression did not benefit from TPF induction chemotherapy. Stathmin expression was an independent predictor of long-term prognosis. CONCLUSIONS: Stathmin is an independent biomarker for predicting the efficacy of TPF induction chemotherapy in OSCC. Subsequent clinical studies based on Stathmin screening will be meaningful for choice of TPF induction chemotherapy in OSCC. |
| Keywords: | Oral squamous cell carcinoma Stathmin Induction chemotherapy Prognosis |
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